Saade Marie Christelle, Clark Amanda J, Parikh Samir M
Division of Nephrology, Department of Medicine, University of Texas Southwestern, Dallas, TX, United States.
Division of Pediatric Nephrology, Department of Pediatrics, University of Texas Southwestern, Dallas, TX, United States.
Front Nutr. 2022 Dec 16;9:1070435. doi: 10.3389/fnut.2022.1070435. eCollection 2022.
Quinolinic acid is an intermediate compound derived from the metabolism of dietary tryptophan. Its accumulation has been reported in patients suffering a broad spectrum of diseases and conditions. In this manuscript, we present the results of a systematic review of research studies assessing urinary quinolinic acid in health and disease.
We performed a literature review using PubMed, Cochrane, and Scopus databases of all studies reporting data on urinary quinolinic acid in human subjects from December 1949 to January 2022.
Fifty-seven articles met the inclusion criteria. In most of the reported studies, compared to the control group, quinolinic acid was shown to be at increased concentration in urine of patients suffering from different diseases and conditions. This metabolite was also demonstrated to correlate with the severity of certain diseases including juvenile idiopathic inflammatory myopathies, graft vs. host disease, autism spectrum disorder, and prostate cancer. In critically ill patients, elevated quinolinic acid in urine predicted a spectrum of adverse outcomes including hospital mortality.
Quinolinic acid has been implicated in the pathophysiology of multiple conditions. Its urinary accumulation appears to be a feature of acute physiological stress and several chronic diseases. The exact significance of these findings is still under investigation, and further studies are needed to reveal the subsequent implications of this accumulation.
喹啉酸是膳食色氨酸代谢产生的一种中间化合物。据报道，在患有多种疾病和病症的患者中其会蓄积。在本论文中，我们展示了一项系统综述的结果，该综述评估了健康及患病状态下尿喹啉酸的研究。
我们使用PubMed、Cochrane和Scopus数据库对1949年12月至2022年1月期间所有报告人体尿喹啉酸数据的研究进行了文献综述。
57篇文章符合纳入标准。在大多数已报道的研究中，与对照组相比，不同疾病和病症患者尿液中的喹啉酸浓度升高。这种代谢物还被证明与某些疾病的严重程度相关，包括青少年特发性炎性肌病、移植物抗宿主病、自闭症谱系障碍和前列腺癌。在重症患者中，尿中喹啉酸升高预示着一系列不良后果，包括医院死亡率。
喹啉酸与多种病症的病理生理学有关。其在尿液中的蓄积似乎是急性生理应激和几种慢性疾病的一个特征。这些发现的确切意义仍在研究中，需要进一步的研究来揭示这种蓄积的后续影响。
