Kumar Ram Bharosh, Karim Tanweer, Jain Atul, Arora Sarika, Katiyar Vivek Kumar, Patel Gaurav
Department of Surgery, ESI PGIMSR, Basaidarapur, New Delhi, India.
Department of Biochemistry, ESI PGIMSR, Basaidarapur, New Delhi, India.
J West Afr Coll Surg. 2022 Oct-Dec;12(4):20-26. doi: 10.4103/jwas.jwas_186_22. Epub 2022 Nov 23.
Early prediction of severity is an important goal in acute pancreatitis (AP), to identify 20% of patients who are likely to have a severe course. Such patients have an expected mortality of 15-20% and may benefit from early admission to high dependency or intensive care units, with parenteral or nasojejunal feeding and prophylactic antibiotics. In severe AP (SAP), multiorgan dysfunction accounts for most of early deaths.
The aim of this article is to assess the role of serum interleukin (IL)-6 and serum C-reactive protein (CRP) in early prediction of severity of AP.
This observational analytical study was conducted in the Department of General Surgery and Department of Biochemistry in our hospital in 62 patients as per inclusion and exclusion criteria.
IL-6 on day 1 and day 2 as well as CRP on day 2 was 100% sensitive but IL-6 on day 1 and day 2 had a maximum specificity of 88.37% among them when compared with a specificity of 81.4% of CRP on day 2. Though CRP on day 1 also had a specificity of 88.37%, its sensitivity was 89.47%.
IL-6 and CRP together appear to be a promising marker for assessing the severity of AP within 48 h. We recommend to do IL-6 and CRP in patients with AP, which can help in predicting severity of the disease in patients.
急性胰腺炎（AP）严重程度的早期预测是一个重要目标，以识别出20%可能经历严重病程的患者。这类患者的预期死亡率为15% - 20%，可能受益于早期入住高依赖或重症监护病房，接受肠外或鼻空肠喂养以及预防性使用抗生素。在重症急性胰腺炎（SAP）中，多器官功能障碍是早期死亡的主要原因。
本文旨在评估血清白细胞介素（IL）-6和血清C反应蛋白（CRP）在AP严重程度早期预测中的作用。
本观察性分析研究于我院普通外科和生物化学科按照纳入和排除标准对62例患者进行。
第1天和第2天的IL - 6以及第2天的CRP敏感性均为100%，但与第2天CRP特异性81.4%相比，第1天和第2天的IL - 6特异性最高为88.37%。虽然第1天的CRP特异性也为88.37%，但其敏感性为89.47%。
IL - 6和CRP共同似乎是48小时内评估AP严重程度的一个有前景的标志物。我们建议对AP患者检测IL - 6和CRP，这有助于预测患者疾病的严重程度。
