Crabbe J C, Young E R, Deutsch C M, Tam B R, Kosobud A
Department of Medical Psychology, Oregon Health Sciences University, Portland.
Pharmacol Biochem Behav. 1987 Jul;27(3):577-81. doi: 10.1016/0091-3057(87)90371-6.
Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.
从基因异质的小鼠群体开始，通过选择性育种来培育对乙醇诱导的旷场活动敏感性不同的品系。小鼠在旷场中进行两次4分钟的测试。第一次测试在注射生理盐水后第2至6分钟进行。24小时后，在注射乙醇（1.5克/千克）后进行类似测试。正在选择两个独立的快速（FAST）品系用于乙醇诱导的活动增加，以及两个独立的慢速（SLOW）品系用于乙醇诱导的活动减少。经过四代选择后，这些品系有了显著差异。这些品系应有助于探索乙醇的激活和奖赏特性的神经药理学基础。
