Mattucci-Schiavone L, Ferko A P
Department of Pharmacology, Hahnemann University, Philadelphia, PA 19102.
Pharmacol Biochem Behav. 1987 Aug;27(4):745-8. doi: 10.1016/0091-3057(87)90202-4.
In male Sprague-Dawley rats acute ethanol (1.0 and 2.0 g/kg) produced impairment of motor coordination and induced hypnosis (4.0 g/kg). Muscimol (1.25 mg/kg, IP) prior to ethanol administration enhanced motor impairment as measured by the aerial righting reflex. The rate of ethanol disappearance from the blood was unaltered by muscimol. Functional tolerance to the effect of ethanol on sleep time was produced by a 24 hr ethanol inhalation procedure. Animals tested 48 hr after ethanol inhalation exhibited a reduced sleep time from ethanol (4.0 g/kg). Muscimol (1.75 mg/kg) was administered along with ethanol 48 hr following 1 day of ethanol inhalation. Although the animals exhibited tolerance to ethanol-induced hypnosis, they did not manifest tolerance to the effect of muscimol.
在雄性斯普拉格-道利大鼠中，急性给予乙醇（1.0和2.0克/千克）会导致运动协调性受损，并诱导催眠（4.0克/千克）。在给予乙醇之前腹腔注射蝇蕈醇（1.25毫克/千克），通过空中翻正反射测量，会增强运动障碍。蝇蕈醇不会改变乙醇从血液中的消失速率。通过24小时乙醇吸入程序可产生对乙醇对睡眠时间影响的功能性耐受性。在乙醇吸入后48小时进行测试的动物，乙醇（4.0克/千克）导致的睡眠时间缩短。在乙醇吸入1天后的48小时，将蝇蕈醇（1.75毫克/千克）与乙醇一起给予。尽管动物对乙醇诱导的催眠表现出耐受性，但它们对蝇蕈醇的作用并未表现出耐受性。
