Mattucci-Schiavone L, Ferko A P
Physiol Behav. 1984 Dec;33(6):895-8. doi: 10.1016/0031-9384(84)90224-5.
It was demonstrated that the aerial righting reflex can be used as an index of acute ethanol-induced impairment of motor coordination in rats, and was found to directly correlate with blood ethanol content from the infraorbital plexus. A study of ethanol within the blood and its distribution in brain regions showed that the ethanol content of orbital sinus blood closely reflected that in the cerebral cortex, midbrain, and cerebellum. Ethanol administration by intraperitoneal (IP) injection (2, 3 or 4 g/kg) produced the same distribution as 24 hr ethanol vapor inhalation (28 mg/l). Blood ethanol concentrations were slightly higher than brain ethanol concentrations when measured at 10, 30, and 60 min after IP injection and immediately following ethanol vapor administration. Also, in rats 48 hr following ethanol vapor inhalation when tolerance to ethanol is exhibited, the distribution and concentrations of ethanol in blood and brain from acute ethanol (2 g/kg, IP) were unaltered when compared with controls. These data suggest that ethanol distribution within the brain does not play a role in the phenomenon of tolerance to ethanol.
结果表明，空中翻正反射可用作大鼠急性乙醇诱导的运动协调障碍的指标，并且发现它与眶下丛的血液乙醇含量直接相关。一项关于血液中乙醇及其在脑区分布的研究表明，眶窦血液中的乙醇含量密切反映了大脑皮层、中脑和小脑中的乙醇含量。通过腹腔注射（IP）（2、3或4 g/kg）给予乙醇与24小时乙醇蒸汽吸入（28 mg/l）产生相同的分布。在腹腔注射后10、30和60分钟以及乙醇蒸汽给药后立即测量时，血液乙醇浓度略高于脑乙醇浓度。此外，在乙醇蒸汽吸入48小时后表现出对乙醇耐受性的大鼠中，与对照组相比，急性乙醇（2 g/kg，IP）在血液和脑中的乙醇分布和浓度没有改变。这些数据表明，脑内乙醇分布在乙醇耐受性现象中不起作用。
