Mattucci-Schiavone L, Ferko A P
Physiol Behav. 1986;36(4):643-6. doi: 10.1016/0031-9384(86)90347-1.
In male Sprague-Dawley rats the acute effect of ethanol administration (1.0, 2.0, or 3.0 g/kg, IP) on motor coordination was measured by the aerial righting reflex. Ethanol in doses of 2.0 and 3.0 g/kg produced significant impairment of motor coordination with corresponding elevated blood ethanol levels. The rate of ethanol dissappearance from the blood was 0.32 +/- 0.03 mg/ml/hr. Functional tolerance to the effect of ethanol on motor coordination and hypnosis (sleep time) was produced in rats by a 24 hr period of exposure to ethanol vapor (28 mg/liter of air) in a chamber. Animals tested 48 hr after the ethanol inhalation period showed less motor impairment from acute ethanol (3.0 g/kg, IP) and other animals exhibited a reduced sleep time from ethanol (4.0 g/kg, IP) when they were compared with controls. The rate of ethanol elimination from the blood was unchanged in ethanol vapor treated animals (0.30 +/- 0.01 mg/ml/hr) and air-treated animals (0.33 +/- 0.02 mg/ml/hr).
在雄性Sprague-Dawley大鼠中，通过空中翻正反射来测定腹腔注射乙醇（1.0、2.0或3.0克/千克）对运动协调性的急性影响。2.0克/千克和3.0克/千克剂量的乙醇会导致运动协调性显著受损，同时血液乙醇水平相应升高。乙醇从血液中的消失速率为0.32±0.03毫克/毫升/小时。通过在一个舱室内让大鼠暴露于乙醇蒸气（28毫克/升空气）24小时，可使其对乙醇在运动协调性和催眠（睡眠时间）方面的作用产生功能性耐受。与对照组相比，在吸入乙醇48小时后接受测试的动物，腹腔注射急性乙醇（3.0克/千克）后运动损伤较小，而其他动物腹腔注射乙醇（4.0克/千克）后睡眠时间缩短。经乙醇蒸气处理的动物（0.30±0.01毫克/毫升/小时）和经空气处理的动物（0.33±0.02毫克/毫升/小时）血液中乙醇的消除速率未发生变化。
