神经肽Y参与注入嗅球切除大鼠内侧杏仁核的去甲肾上腺素的抗杀鼠剂作用。

The involvement of neuropeptide Y in the antimuricide action of noradrenaline injected into the medial amygdala of olfactory bulbectomized rats.

作者信息

Kataoka Y, Sakurai Y, Mine K, Yamashita K, Fujiwara M, Niwa M, Ueki S

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

Pharmacol Biochem Behav. 1987 Sep;28(1):101-3. doi: 10.1016/0091-3057(87)90019-0.

DOI:10.1016/0091-3057(87)90019-0

PMID:3659100

Abstract

The present study was designed to clarify the functional role of neuropeptide Y (NPY) in the regulation of muricide induced by olfactory bulbectomy (OB) in relation to that of noradrenaline (NA) in the medial amygdala (AME). NA injected into AME inhibited muricide dose-dependently in OB rats. NPY at doses of 5 and 10 micrograms/microliter injected alone into AME failed to suppress muricide. When NPY 10 micrograms was injected into AME in combination with the maximal non-effective dose of NA, which was determined in each rat, muricide was suppressed in 80% of OB rats. The present study has provided the first evidence suggesting that NPY may be involved in the regulation of OB-induced muricide.

摘要

本研究旨在阐明神经肽Y（NPY）在嗅球切除（OB）诱导的杀鼠行为调节中的功能作用，及其与内侧杏仁核（AME）中去甲肾上腺素（NA）的关系。向AME注射NA可剂量依赖性地抑制OB大鼠的杀鼠行为。单独向AME注射5和10微克/微升剂量的NPY未能抑制杀鼠行为。当将10微克NPY与每只大鼠确定的最大无效剂量的NA联合注射到AME中时，80%的OB大鼠的杀鼠行为受到抑制。本研究首次提供了证据表明NPY可能参与OB诱导的杀鼠行为的调节。