Al-Khatib I M, Fujiwara M, Kataoka Y, Ueki S
Department of Pharmacology, College of Medicine, University of Salahaddin, Erbil, Iraq.
Arch Int Pharmacodyn Ther. 1988 Nov-Dec;296:282-92.
The effects of olfactory bulbectomy (OB) and nomifensine (NOM) on the binding of [3H]-imipramine (3H-IMP) in brain of rat were investigated. Seventy-five per cent of OB rats exhibited muricide. Acute NOM suppressed muricide in 55% and chronic NOM suppressed it in 60 80% of OB rats. In killer rats, OB increased Bmax of high-affinity (HA) and low-affinity sites (LA) in cortex (Cx) and both Bmax and KD of HA in amygdala (AMG). In rats with muricide suppressed by acute NOM 10 mg.kg-1 i.p., Bmax and KD of HA in Cx and of both HA and LA in AMG were reduced. Injection of NOM for 10 days produced further reduction of Bmax, especially of HA binding in Cx. Neither OB nor NOM exerted any significant effect on binding constants in caudate-putamen and hypothalamus. The possible relation between the changes of 3H-IMP binding, exhibition of muricide by OB rats and the antimuricidal activity of NOM are discussed.
研究了嗅球切除（OB）和诺米芬辛（NOM）对大鼠脑中[3H]-丙咪嗪（3H-IMP）结合的影响。75%的OB大鼠表现出杀鼠行为。急性NOM抑制了55%的OB大鼠的杀鼠行为，慢性NOM抑制了60 - 80%的OB大鼠的杀鼠行为。在有杀鼠行为的大鼠中，OB增加了皮质（Cx）中高亲和力（HA）和低亲和力位点（LA）的Bmax，以及杏仁核（AMG）中HA的Bmax和KD。在腹腔注射10mg·kg-1急性NOM抑制杀鼠行为的大鼠中，Cx中HA的Bmax和KD以及AMG中HA和LA的Bmax和KD均降低。注射NOM 10天导致Bmax进一步降低，尤其是Cx中HA结合的降低。OB和NOM对尾状核-壳核和下丘脑的结合常数均无显著影响。讨论了3H-IMP结合变化、OB大鼠杀鼠行为的表现与NOM的抗杀鼠活性之间的可能关系。
