Ferrer J M, Cobo M, Mora F
Department of Physiology, Faculty of Medicine, University of Granada, Spain.
Physiol Behav. 1987;40(3):291-5. doi: 10.1016/0031-9384(87)90049-7.
The effects of lesions of the basolateral nucleus of the amygdala (ABL) and the mediodorsal nucleus of the thalamus (MD) on self-stimulation (SS) of the medial prefrontal cortex (MPC) were investigated. Spontaneous motor activity (SMA) was measured as a control for possible non-specific effects of the lesions. Bilateral electrolytic lesions of ABL or MD produced a parallel transient decrease of SS and SMA. However, combined lesion of ABL and MD produced clearly different effects on both parameters. SMA decreased during the 1st day post-lesion and recovered to control levels by the 3rd day post-lesion. SS, on the contrary, was significantly decreased during the first five days post-lesion and after that time SS rate recovered to control levels. These results suggest the involvement of the basolateral limbic circuit in the neural substate underlying SS behavior of the MPC.
研究了杏仁核基底外侧核（ABL）和丘脑背内侧核（MD）损伤对内侧前额叶皮质（MPC）自我刺激（SS）的影响。测量自发运动活动（SMA）作为损伤可能产生的非特异性效应的对照。ABL或MD的双侧电解损伤导致SS和SMA平行短暂下降。然而，ABL和MD的联合损伤对这两个参数产生了明显不同的影响。SMA在损伤后第1天下降，并在损伤后第3天恢复到对照水平。相反，SS在损伤后的前五天显著下降，此后SS速率恢复到对照水平。这些结果表明基底外侧边缘回路参与了MPC的SS行为背后的神经亚状态。
