• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

正电子发射断层扫描/计算机断层扫描（PET/CT）成像在阿霉素诱导的粘膜炎小鼠模型中检测到肠道炎症。

PET/CT imaging detects intestinal inflammation in a mouse model of doxorubicin-induced mucositis.

作者信息

Dalby Sina, Skallerup Sofie, Baun Christina, Christensen Lene Gaarsmand, Rathe Mathias, Palner Mikael, Husby Steffen, Moeller Jesper Bonnet

机构信息

Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.

Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

出版信息

Front Oncol. 2022 Dec 15;12:1061804. doi: 10.3389/fonc.2022.1061804. eCollection 2022.

DOI:10.3389/fonc.2022.1061804
PMID:36591502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9798215/
Abstract

INTRODUCTION

A severe side effect of cancer chemotherapy is the development of gastrointestinal mucositis, characterised by mucosal inflammation. We investigated if 2-deoxy-2-[F] fluoro-D-glucose positron emission tomography combined with computed tomography (2-[F]FDG-PET/CT) could visualise gastrointestinal mucositis in mice treated with the chemotherapeutic agent doxorubicin.

METHODS

In this study, gastrointestinal inflammation was longitudinally evaluated by 2-[F]FDG-PET/CT scans before and 1, 3, 6, and 10 days after treatment with doxorubicin. Doxorubicin-treated mice were compared to saline-treated littermates using the abdominal standard uptake value of 2-[F]FDG corrected for body weight (SUV).

RESULTS

Abdominal SUV was significantly increased on day 1 (p < 0.0001), day 3 (p < 0.0001), and day 6 (p < 0.05) in the doxorubicin-treated group compared to controls. Abdominal SUV returned to baseline levels on day 10. In the doxorubicin group, the largest weight loss was observed on day 3 (control doxorubicin, mean percent of baseline weight: (98.5 ± 3.2% 87.9 ± 4.6%, p < 0.0001). Moreover, in the doxorubicin-treated group, villus lengths were decreased by 23-28% on days 1 and 3 in the small intestine (p < 0.05), and jejunal levels of tumour necrosis factor and interleukin-1β were significantly increased on day 3 (p < 0.05).

DISCUSSION

Together, these findings indicate that sequential 2-[F]FDG-PET/CT scans can objectively quantify and evaluate the development and resolution of intestinal inflammation over time in a mouse model of doxorubicin-induced mucositis.

摘要

引言

癌症化疗的一种严重副作用是胃肠道粘膜炎的发生，其特征为粘膜炎症。我们研究了2-脱氧-2-[F]氟-D-葡萄糖正电子发射断层扫描联合计算机断层扫描（2-[F]FDG-PET/CT）是否能够使接受化疗药物阿霉素治疗的小鼠的胃肠道粘膜炎可视化。

方法

在本研究中，通过2-[F]FDG-PET/CT扫描在阿霉素治疗前以及治疗后1、3、6和10天对胃肠道炎症进行纵向评估。使用经体重校正的2-[F]FDG的腹部标准摄取值（SUV），将接受阿霉素治疗的小鼠与其接受生理盐水治疗的同窝仔鼠进行比较。

结果

与对照组相比，阿霉素治疗组在第1天（p < 0.0001）、第3天（p < 0.0001）和第6天（p < 0.05）腹部SUV显著升高。腹部SUV在第10天恢复到基线水平。在阿霉素组中，第3天观察到最大体重减轻（对照组对阿霉素组，平均基线体重百分比：(98.5 ± 3.2%对87.9 ± 4.6%，p < 0.0001）。此外，在阿霉素治疗组中，小肠在第1天和第3天绒毛长度减少了23 - 28%（p < 0.05），空肠肿瘤坏死因子和白细胞介素-1β水平在第3天显著升高（p < 0.05）。

讨论

总之，这些发现表明，连续的2-[F]FDG-PET/CT扫描能够在阿霉素诱导的粘膜炎小鼠模型中随时间客观地量化和评估肠道炎症的发生和消退情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/5d8359d5fcb1/fonc-12-1061804-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/bdcfe441ae4b/fonc-12-1061804-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/06d9d84e14d3/fonc-12-1061804-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/334d49dfde9e/fonc-12-1061804-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/a08a79a11c48/fonc-12-1061804-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/49bb0f7be5ad/fonc-12-1061804-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/c9c92c8bc79f/fonc-12-1061804-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/5d8359d5fcb1/fonc-12-1061804-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/bdcfe441ae4b/fonc-12-1061804-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/06d9d84e14d3/fonc-12-1061804-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/334d49dfde9e/fonc-12-1061804-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/a08a79a11c48/fonc-12-1061804-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/49bb0f7be5ad/fonc-12-1061804-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/c9c92c8bc79f/fonc-12-1061804-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea52/9798215/5d8359d5fcb1/fonc-12-1061804-g007.jpg

相似文献

1
PET/CT imaging detects intestinal inflammation in a mouse model of doxorubicin-induced mucositis.正电子发射断层扫描/计算机断层扫描（PET/CT）成像在阿霉素诱导的粘膜炎小鼠模型中检测到肠道炎症。
Front Oncol. 2022 Dec 15;12:1061804. doi: 10.3389/fonc.2022.1061804. eCollection 2022.
2
More advantages in detecting bone and soft tissue metastases from prostate cancer using F-PSMA PET/CT.使用F-PSMA PET/CT检测前列腺癌骨和软组织转移方面有更多优势。
Hell J Nucl Med. 2019 Jan-Apr;22(1):6-9. doi: 10.1967/s002449910952. Epub 2019 Mar 7.
3
Doxorubicin Effect on Myocardial Metabolism as a Prerequisite for Subsequent Development of Cardiac Toxicity: A Translational F-FDG PET/CT Observation.多柔比星对心肌代谢的影响是随后发生心脏毒性的前提：一项 F-FDG PET/CT 的转化观察。
J Nucl Med. 2017 Oct;58(10):1638-1645. doi: 10.2967/jnumed.117.191122. Epub 2017 Jun 23.
4
18-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scan for monitoring the therapeutic response in experimental Staphylococcus aureus foreign-body osteomyelitis.18-氟-2-脱氧-D-葡萄糖正电子发射断层扫描/计算机断层扫描用于监测实验性金黄色葡萄球菌异物性骨髓炎的治疗反应
J Orthop Surg Res. 2015 Aug 27;10:132. doi: 10.1186/s13018-015-0274-9.
5
Ferret thoracic anatomy by 2-deoxy-2-(18F)fluoro-D-glucose (18F-FDG) positron emission tomography/computed tomography (18F-FDG PET/CT) imaging.通过2-脱氧-2-（18F）氟-D-葡萄糖（18F-FDG）正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）成像对雪貂胸部解剖结构的研究。
ILAR J. 2012;53(1):E9-21. doi: 10.1093/ilar.53.1.9.
6
Cancer immunotherapy is accompanied by distinct metabolic patterns in primary and secondary lymphoid organs observed by non-invasive F-FDG-PET.癌症免疫疗法伴随着原发性和继发性淋巴器官中通过非侵入性 F-FDG-PET 观察到的独特代谢模式。
Theranostics. 2020 Jan 1;10(2):925-937. doi: 10.7150/thno.35989. eCollection 2020.
7
Monitoring therapy with MEK inhibitor U0126 in a novel Wilms tumor model in Wt1 knockout Igf2 transgenic mice using 18F-FDG PET with dual-contrast enhanced CT and MRI: early metabolic response without inhibition of tumor growth.使用 18F-FDG PET 联合双对比增强 CT 和 MRI 监测 MEK 抑制剂 U0126 在 Wt1 敲除 Igf2 转基因小鼠新型 Wilms 肿瘤模型中的治疗效果：无肿瘤生长抑制的早期代谢反应。
Mol Imaging Biol. 2013 Apr;15(2):175-85. doi: 10.1007/s11307-012-0588-5.
8
Appearance of aseptic vascular grafts after endovascular aortic repair on [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography.经皮腔内主动脉修复术后无菌血管移植物在[（18）F]氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描上的表现
World J Radiol. 2023 Aug 28;15(8):241-249. doi: 10.4329/wjr.v15.i8.241.
9
Response to chemotherapy in gastric adenocarcinoma with diffusion-weighted MRI and (18) F-FDG-PET/CT: correlation of apparent diffusion coefficient and partial volume corrected standardized uptake value with histological tumor regression grade.弥散加权磁共振成像和（18）F-FDG-PET/CT评估胃腺癌化疗疗效：表观扩散系数和部分容积校正标准化摄取值与组织学肿瘤退缩分级的相关性
J Magn Reson Imaging. 2014 Nov;40(5):1147-57. doi: 10.1002/jmri.24464. Epub 2013 Nov 8.
10
Early Post-ischemic Brain Glucose Metabolism Is Dependent on Function of TLR2: a Study Using [F]F-FDG PET-CT in a Mouse Model of Cardiac Arrest and Cardiopulmonary Resuscitation.早期脑缺血后葡萄糖代谢依赖于 TLR2 的功能：一项使用 [F]F-FDG PET-CT 在心脏骤停和心肺复苏小鼠模型中的研究。
Mol Imaging Biol. 2022 Jun;24(3):466-478. doi: 10.1007/s11307-021-01677-y. Epub 2021 Nov 15.

引用本文的文献

1
RIP3 regulates doxorubicin-induced intestinal mucositis via FUT2-mediated α-1,2-fucosylation.RIP3 通过 FUT2 介导的 α-1,2-岩藻糖基化调节多柔比星诱导的肠道黏膜炎。
Inflamm Res. 2024 Oct;73(10):1781-1801. doi: 10.1007/s00011-024-01932-2. Epub 2024 Aug 24.

本文引用的文献

1
No effect of deleted in malignant brain tumors 1 deficiency on chemotherapy induced murine intestinal mucositis.恶性脑瘤 1 缺失缺失对化疗诱导的小鼠肠道黏膜炎无影响。
Sci Rep. 2021 Jul 19;11(1):14687. doi: 10.1038/s41598-021-94076-w.
2
Peptidoglycan Recognition Peptide 2 Aggravates Weight Loss in a Murine Model of Chemotherapy-Induced Gastrointestinal Toxicity.肽聚糖识别肽2加重化疗诱导的胃肠道毒性小鼠模型中的体重减轻。
Front Oncol. 2021 Mar 23;11:635005. doi: 10.3389/fonc.2021.635005. eCollection 2021.
3
Imaging Inflammation with Positron Emission Tomography.
利用正电子发射断层扫描成像炎症
Biomedicines. 2021 Feb 19;9(2):212. doi: 10.3390/biomedicines9020212.
4
FIBCD1 ameliorates weight loss in chemotherapy-induced murine mucositis.FIBCD1 可改善化疗诱导的小鼠黏膜炎所致体重下降。
Support Care Cancer. 2021 May;29(5):2415-2421. doi: 10.1007/s00520-020-05762-w. Epub 2020 Sep 12.
5
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research.ARRIVE 指南 2.0：报告动物研究的更新指南。
BMC Vet Res. 2020 Jul 14;16(1):242. doi: 10.1186/s12917-020-02451-y.
6
Prediction of mucositis risk secondary to cancer therapy: a systematic review of current evidence and call to action.预测癌症治疗相关的口腔黏膜炎风险：当前证据的系统评价和行动呼吁。
Support Care Cancer. 2020 Nov;28(11):5059-5073. doi: 10.1007/s00520-020-05579-7. Epub 2020 Jun 26.
7
Oral Mucositis: An Update on Innate Immunity and New Interventional Targets.口腔黏膜炎：固有免疫与新介入靶点的最新进展
J Dent Res. 2020 Sep;99(10):1122-1130. doi: 10.1177/0022034520925421. Epub 2020 Jun 1.
8
Pitfalls and novel experimental approaches to optimize microbial interventions for chemotherapy-induced gastrointestinal mucositis.优化化疗诱导的胃肠道黏膜炎微生物干预措施的陷阱与新型实验方法
Curr Opin Support Palliat Care. 2020 Jun;14(2):127-134. doi: 10.1097/SPC.0000000000000497.
9
Evaluation of Clostridium difficile Infection with PET/CT Imaging in a Mouse Model.利用 PET/CT 成像技术在小鼠模型中评估艰难梭菌感染。
Mol Imaging Biol. 2020 Jun;22(3):587-592. doi: 10.1007/s11307-019-01408-4.
10
The pathogenesis of mucositis: updated perspectives and emerging targets.黏膜炎发病机制：最新观点和新兴靶点。
Support Care Cancer. 2019 Oct;27(10):4023-4033. doi: 10.1007/s00520-019-04893-z. Epub 2019 Jul 8.