Turk Psikiyatri Derg. 2022 Winter;33(4):233-247. doi: 10.5080/u26956.
In this study, the losses of neurocognitive function caused by the use of cannabis and synthetic cannabinoid were studied on specific cognitive areas (attention and working memory, executive functions, visuospatial perception, learning and memory, planning and problem solving, word naming) and were described in comparision with healthy controls (control group).
In this study, while 52 participants who applied to Ege University Faculty of Medicine Department of Mental Health and Mental Disorders Drug Addiction Treatment Center Clinic between March 2015 - February 2017 and used cannabis at least for one year in the past and 51 participants who used synthetic cannabinoids for at least one year in the past were participant groups with a history of substance use; 57 staff/student of Ege University with no history of any substance use were participants of the control group. The research sample consisted of 160 participants. The sample group consisted of 160 men aged 18-35, and also 16 participants aged 36-54 were involved in the study in order to observe neuropsychological functions that changed with age. Stroop Test for attention area, Raven Standart Progressive Matrices Test for executive functions area, Line Orientation Test and Cancellation Test for visuospatial perception area, Serial Digit Learning Test and Öktem Verbal Memory Progresses Scale for learning and memory area, The Tower of London Test for planning and problem solving skill, Boston Naming Test for word naming area were used.
In this study, while the lowest perfomance on the ability of focused attention, visuospatial cognition, visual scanning, orientation, sustained attention, general ability, short-term memory, learning, long-term memory, word naming was shown by the participants with a history of synthetic cannabis use, the participants with a history of cannabis use had the lowest performance on the ability of response rate, perseveration, conceptualizing, abstract thinking, changing sets, recognition. Participants' history of substance use did not affect the ability of planning and problem solving.
In conclusion, this study suggests that the addition of cognitive rehabilitation programs to medical and psychosocial improvement studies carried out in the field of addiction will increase the success.
本研究旨在研究使用大麻和合成大麻素对特定认知领域（注意力和工作记忆、执行功能、视空间感知、学习和记忆、计划和解决问题、命名）的神经认知功能的损害，并与健康对照组（对照组）进行比较。
本研究中，将 2015 年 3 月至 2017 年 2 月期间至少在过去一年中使用过大麻且至少在过去一年中使用过合成大麻素的 52 名参与者作为有物质使用史的参与者组，以及 51 名参与者作为有物质使用史的参与者组；将没有任何物质使用史的 57 名伊兹密尔大学教职员工/学生作为对照组的参与者。研究样本由 160 名参与者组成。样本组由 160 名年龄在 18-35 岁之间的男性组成，还包括 16 名年龄在 36-54 岁之间的参与者，以观察随年龄变化的神经心理功能。使用 Stroop 测试（注意力区域）、Raven 标准渐进矩阵测试（执行功能区域）、线定向测试和取消测试（视空间感知区域）、序列数字学习测试和Öktem 言语记忆进展量表（学习和记忆区域）、伦敦塔测试（规划和解决问题技能）、波士顿命名测试（命名区域）。
在这项研究中，合成大麻素使用史组参与者在集中注意力、视空间认知、视觉扫描、定向、持续注意力、一般能力、短期记忆、学习、长期记忆、命名能力方面表现出最低的能力，而大麻使用史组参与者在反应速度、坚持、概念化、抽象思维、改变集、识别能力方面表现出最低的能力。参与者的物质使用史并未影响计划和解决问题的能力。
总之，本研究表明，在成瘾领域开展的医疗和社会心理改善研究中增加认知康复计划将提高成功率。
