Wieler H, Hoffmanns H W, Kippels A, Huhndorf S, Düx A
Krankenhaus Maria Hilf GmbH, Radiologische Klinik, Mönchengladbach, Federal Republic of Germany.
Radiat Environ Biophys. 1987;26(3):219-26. doi: 10.1007/BF01213708.
The simultaneous use of intraarterial Cis-Platinum and Radiotherapy (CP/RT) was found to be a very effective and relatively little burdened treatment for a palliative treatment concept. This affects life quality as well as the remission--and survival times. The fast and continual remission with low CP/RT concentrations, even in extreme palliative cases, is surprising. CP/RT treatment shows additive and synergistic effects which are not explainable by the single effects of the cis-platinum dose used (60 mg/1.73 m2 in our case) or the total irradiation dose (e.g., 5 Gy TD) or the fractionation (e.g., 5 X 1 Gy), especially since the doses of each which were used are by themselves without therapeutic relevance. Only the combination of the modalities with a low dose two-day preradiation program induced the described effects.
动脉内顺铂与放疗同步使用（CP/RT）被发现是一种非常有效的姑息治疗方案，且负担相对较小。这对生活质量以及缓解期和生存期都有影响。即使在极端姑息治疗的情况下，低CP/RT浓度也能实现快速且持续的缓解，这令人惊讶。CP/RT治疗显示出相加和协同效应，这无法用所使用的顺铂剂量（我们的病例中为60mg/1.73m²）、总照射剂量（例如5Gy TD）或分割方式（例如5×1Gy）的单一效应来解释，特别是因为所使用的每种剂量本身都没有治疗相关性。只有采用低剂量两天预放疗方案的联合治疗方式才产生了上述效果。
