Gefeller D, Renner K, Slomska J
Strahlentherapie. 1985 Jan;161(1):5-12.
Since January 1982, we have treated in a phase-II study 28 patients with a low-dose cis-platinum therapy combined with radiotherapy. We wanted to study the effect of reduced doses of cis-diamino-dichloroplatinum (II) in three different dose patterns: 1. "higher" dosage (150 mg/m2 within six weeks), single dose: 25 mg/m2 one time per treatment week), 2. "medium" dosage (80 mg/m2 within six weeks), single dose: 20 mg/m2 two times weekly during the first, fourth, seventh, and tenth treatment week, 3. "lower" dosage (75 mg/m2 within six weeks), single dose: 12.5 mg/m2 three times weekly during the first, fourth, seventh, and tenth treatment week. In one patient group the simultaneous radiotherapy was performed with a tumoricide dose of 2 Gy single dose with 4 fractions per week in two series (first series about 40 to 48 Gy tumor dose, pause of three to four weeks, second series about 16 Gy focal dose). The other group received palliative radiation doses (10 to 35 Gy tumor dose in one series), and the total platinum doses were lower corresponding to the shorter irradiation time. All patients were in advanced or recurrent stages of the disease. They suffered from different carcinomas and sarcomas with measurable parameters of response.
自1982年1月起，我们在一项II期研究中对28例患者采用低剂量顺铂疗法联合放疗进行治疗。我们想研究三种不同剂量模式下顺二氨基二氯铂（II）剂量降低的效果：1. “较高”剂量（六周内150mg/m²），单次剂量：每次治疗周25mg/m²，共一次；2. “中等”剂量（六周内80mg/m²），单次剂量：在第一、第四、第七和第十治疗周每周两次，每次20mg/m²；3. “较低”剂量（六周内75mg/m²），单次剂量：在第一、第四、第七和第十治疗周每周三次，每次12.5mg/m²。在一组患者中，同步放疗采用肿瘤致死剂量，单次剂量2Gy，每周4次，分两个疗程（第一个疗程肿瘤剂量约40至48Gy，间隔三至四周，第二个疗程局部剂量约16Gy）。另一组接受姑息性放射剂量（一个疗程肿瘤剂量10至35Gy），且由于照射时间较短，总铂剂量相应较低。所有患者均处于疾病的晚期或复发阶段。他们患有不同的癌和肉瘤，有可测量的反应参数。
