Douple E B, Richmond R C
Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):501-3. doi: 10.1016/0360-3016(82)90670-8.
This study examines two ways to enhance cisplatin-mediated potentiation of the radiotherapy of a mouse mammary tumor, MTG-B: a) the appropriate sequencing of the two modalities, and b) the use of platinum "rescue" at appropriate times relative to injection of cisplatin to ameliorate platinum toxicity and permit the use of larger concentrations of cisplatin. Reduced TCD50 values and potentiated tumor regression resulted when cisplatin preceded irradiation by 1 hr compared to injection of cisplatin post-irradiation. Cisplatin "rescue" was demonstrated by DDTC, WR-2721 and 5-TG, and enhanced effects on the inhibition of tumor growth resulted when 20 mg/kg cisplatin and 730 mg/kg DDTC were combined with radiotherapy.
本研究探讨了增强顺铂介导的小鼠乳腺肿瘤MTG-B放射治疗增效作用的两种方法：a）两种治疗方式的适当顺序，以及b）在相对于顺铂注射的适当时间使用铂“解救”以减轻铂毒性，并允许使用更高浓度的顺铂。与放疗后注射顺铂相比，顺铂在放疗前1小时注射时，TCD50值降低，肿瘤消退增强。二乙基二硫代氨基甲酸钠（DDTC）、WR-2721和5-硫代甘油（5-TG）证明了顺铂“解救”的作用，当20mg/kg顺铂和730mg/kg DDTC与放疗联合使用时，对肿瘤生长抑制的效果增强。
