Cliniques Universitaires Saint Luc, Avenue Hippocrate 10, 1200, Brussels, Belgium.
Arch Orthop Trauma Surg. 2023 Aug;143(8):5269-5275. doi: 10.1007/s00402-022-04754-1. Epub 2023 Jan 3.
Oxidized zirconium (Oxinium), titanium nitride (TiN) or titanium niobium nitride (TiNbN) coated implants became in recent years available for an increasing amount of total knee arthroplasty (TKA) systems. The hypothesis of this study was that the use of TiNbN-coated components would not lead to inferior results compared to conventional implants and that none of the metal hypersensitivity patients receiving TiNbN-coated implants would require revision for metal allergy.
This retrospective study compared 53 Titanium Niobium Nitride coated TKA with 103 conventional chrome cobalt implants of the same design. Patients were evaluated at a minimal follow-up of 3 years.
No differences in clinical, radiological or patient-reported outcome measurements were observed between these groups. A survivorship of 96% without differences in revision rates was observed at medium-term follow-up of 6.5 years.
Metal allergy leading to contact or generalized dermatitis after TKA is very rare and usually linked to chrome or cobalt hypersensitivity. Nickel release from knee implants has not been shown to lead to cutaneous symptoms, but unexplained pain and swelling, peri-prosthetic osteolysis and component loosening remain potential issues not fully understood. The use of coated implants eliminates this factor from the diagnostic equation in case of postoperative dissatisfaction.
The use of titanium niobium nitride coated implants for primary knee osteoarthritis in self-reported metal hypersensitivity patients shows similar outcomes and survivorship rates as conventional chrome cobalt TKA, with no revisions for allergy at medium-term follow-up.
近年来,氧化锆(Oxinium)、氮化钛(TiN)或钛铌氮化物(TiNbN)涂层植入物越来越多地应用于全膝关节置换术(TKA)系统。本研究的假设是,与传统植入物相比,使用 TiNbN 涂层部件不会导致结果不佳,并且接受 TiNbN 涂层植入物的金属过敏患者中无一例因金属过敏需要进行翻修。
本回顾性研究比较了 53 例 TiNbN 涂层 TKA 与 103 例相同设计的传统铬钴植入物。患者的随访时间至少为 3 年。
在这些组之间未观察到临床、影像学或患者报告的结果测量有差异。在 6.5 年的中期随访中,观察到无差异的翻修率,存活率为 96%。
TKA 后导致接触性皮炎或全身性皮炎的金属过敏非常罕见,通常与铬或钴过敏有关。从膝关节植入物中释放的镍并未导致皮肤症状,但未解释的疼痛和肿胀、假体周围骨溶解和组件松动仍然是尚未完全理解的潜在问题。在术后不满意的情况下,使用涂层植入物可将此因素从诊断方程中排除。
在自述金属过敏的原发性膝骨关节炎患者中使用钛铌氮化物涂层植入物,与传统铬钴 TKA 相比,具有相似的结果和存活率,在中期随访中没有因过敏而进行翻修。