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在中期随访中,钛铌氮膝关节植入物并不逊于铬钴部件用于初次全膝关节置换术。

Titanium niobium nitride knee implants are not inferior to chrome cobalt components for primary total knee arthroplasty at medium-term follow-up.

机构信息

Cliniques Universitaires Saint Luc, Avenue Hippocrate 10, 1200, Brussels, Belgium.

出版信息

Arch Orthop Trauma Surg. 2023 Aug;143(8):5269-5275. doi: 10.1007/s00402-022-04754-1. Epub 2023 Jan 3.

DOI:10.1007/s00402-022-04754-1
PMID:36595031
Abstract

BACKGROUND

Oxidized zirconium (Oxinium), titanium nitride (TiN) or titanium niobium nitride (TiNbN) coated implants became in recent years available for an increasing amount of total knee arthroplasty (TKA) systems. The hypothesis of this study was that the use of TiNbN-coated components would not lead to inferior results compared to conventional implants and that none of the metal hypersensitivity patients receiving TiNbN-coated implants would require revision for metal allergy.

MATERIALS AND METHODS

This retrospective study compared 53 Titanium Niobium Nitride coated TKA with 103 conventional chrome cobalt implants of the same design. Patients were evaluated at a minimal follow-up of 3 years.

RESULTS

No differences in clinical, radiological or patient-reported outcome measurements were observed between these groups. A survivorship of 96% without differences in revision rates was observed at medium-term follow-up of 6.5 years.

DISCUSSION

Metal allergy leading to contact or generalized dermatitis after TKA is very rare and usually linked to chrome or cobalt hypersensitivity. Nickel release from knee implants has not been shown to lead to cutaneous symptoms, but unexplained pain and swelling, peri-prosthetic osteolysis and component loosening remain potential issues not fully understood. The use of coated implants eliminates this factor from the diagnostic equation in case of postoperative dissatisfaction.

CONCLUSION

The use of titanium niobium nitride coated implants for primary knee osteoarthritis in self-reported metal hypersensitivity patients shows similar outcomes and survivorship rates as conventional chrome cobalt TKA, with no revisions for allergy at medium-term follow-up.

摘要

背景

近年来,氧化锆(Oxinium)、氮化钛(TiN)或钛铌氮化物(TiNbN)涂层植入物越来越多地应用于全膝关节置换术(TKA)系统。本研究的假设是,与传统植入物相比,使用 TiNbN 涂层部件不会导致结果不佳,并且接受 TiNbN 涂层植入物的金属过敏患者中无一例因金属过敏需要进行翻修。

材料与方法

本回顾性研究比较了 53 例 TiNbN 涂层 TKA 与 103 例相同设计的传统铬钴植入物。患者的随访时间至少为 3 年。

结果

在这些组之间未观察到临床、影像学或患者报告的结果测量有差异。在 6.5 年的中期随访中,观察到无差异的翻修率,存活率为 96%。

讨论

TKA 后导致接触性皮炎或全身性皮炎的金属过敏非常罕见,通常与铬或钴过敏有关。从膝关节植入物中释放的镍并未导致皮肤症状,但未解释的疼痛和肿胀、假体周围骨溶解和组件松动仍然是尚未完全理解的潜在问题。在术后不满意的情况下,使用涂层植入物可将此因素从诊断方程中排除。

结论

在自述金属过敏的原发性膝骨关节炎患者中使用钛铌氮化物涂层植入物,与传统铬钴 TKA 相比,具有相似的结果和存活率,在中期随访中没有因过敏而进行翻修。

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Metal wear debris generation in primary total knee arthroplasty: is it an issue?初次全膝关节置换术中金属磨损颗粒的产生:这是一个问题吗?
Acta Orthop Belg. 2021 Dec;87(4):681-695. doi: 10.52628/87.4.13.
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"Systematic review and meta-analysis of ceramic coated implants in total knee arthroplasty. Comparable mid-term results to uncoated implants.".全膝关节置换术中陶瓷涂层植入物的系统评价与荟萃分析。中期结果与未涂层植入物相当。
Knee Surg Sports Traumatol Arthrosc. 2023 Mar;31(3):839-851. doi: 10.1007/s00167-021-06775-6. Epub 2021 Oct 29.
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Ceramic Coating in Cemented Primary Total Knee Arthroplasty is Not Associated With Decreased Risk of Revision due to Early Prosthetic Joint Infection.
Revisiting the universal femoral component: Midterm outcomes of a modern design.
重新审视通用型股骨假体:一种现代设计的中期结果。
J Orthop. 2024 Jul 15;58:150-153. doi: 10.1016/j.jor.2024.06.042. eCollection 2024 Dec.
水泥型初次全膝关节置换术中陶瓷涂层与降低因早期假体关节感染而翻修的风险无关。
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Retrieval study of commercially available knee implant coatings TiN, TiNbN and ZrN on TiAl6V4 and CoCr28Mo6.商用膝关节植入物涂层 TiN、TiNbN 和 ZrN 在 TiAl6V4 和 CoCr28Mo6 上的检索研究。
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Retrieval analysis of TiN (titanium nitride) coated knee replacements: Coating wear and degradation in vivo.氮化钛(TiN)涂层膝关节置换物的检索分析:体内涂层磨损与降解
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Allergy in total knee arthroplasty: a review of the facts.全膝关节置换术中的过敏反应:事实回顾
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No Increased Risk of Knee Arthroplasty Failure in Patients With Positive Skin Patch Testing for Metal Hypersensitivity: A Matched Cohort Study.金属超敏反应皮肤斑贴试验阳性患者行膝关节置换术失败风险未增加:一项配对队列研究。
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Titanium niobium nitride knee implants are not inferior to chrome cobalt components for primary total knee arthroplasty.对于初次全膝关节置换术,氮化钛铌膝关节植入物并不逊色于铬钴部件。
Arch Orthop Trauma Surg. 2015 Dec;135(12):1749-54. doi: 10.1007/s00402-015-2320-9. Epub 2015 Aug 29.
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Prevalence of self-reported metal allergy in patients undergoing primary total knee arthroplasty.初次全膝关节置换术患者自我报告的金属过敏患病率。
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