伤口疼痛和伤口愈合生物标志物来自伤口渗出液：范围综述。
Wound Pain and Wound Healing Biomarkers From Wound Exudate: A Scoping Review.
机构信息
Taichi Goto, PhD, RN, PHN, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland; and JSPS Overseas Research Fellowship, Tokyo, Japan.
Leorey N. Saligan, PhD, RN, CRNP, FAAN, National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland.
出版信息
J Wound Ostomy Continence Nurs. 2020 Nov/Dec;47(6):559-568. doi: 10.1097/WON.0000000000000703.
PURPOSE
Effective management of wound pain is essential for optimal wound healing. Nevertheless, the outcomes of wound pain interventions are based on subjective measures, which can prove problematic in patients with cognitive impairment. Identification of biomarkers associated with wound pain and wound healing can be used to more objectively estimate wound pain and contribute to the development of precise management options to reduce wound pain and promote wound healing. This scoping review aimed to identify wound pain and wound healing biomarkers from wound exudates and to describe different wound collection methods to identify these biomarkers.
METHODS
We searched the literature (PROSPERO database registration number: CRD42018103843) via a scoping review.
SEARCH STRATEGY
The PubMed database was searched for articles that explored relationships between cutaneous wound pain, wound healing, and biomolecules. Inclusion criteria were articles that reported original data, used adult human samples, and were published in English.
FINDINGS
Twenty-one articles were retrieved: 17 investigated molecules from wound exudate associated with wound healing status, and 4 reported molecules associated with wound pain. The most frequently observed wound pain biomarkers were proinflammatory cytokines; the most frequently observed wound healing biomarkers were proteases including those in the matrix metalloproteinase family. Six wound exudate collection methods were identified to extract potential wound pain and wound healing biomarkers from wound exudate.
IMPLICATIONS
The results can guide future wound exudate research to validate these wound pain and wound healing biomarkers and to develop therapies targeting these biomarkers to reduce wound pain and promote wound healing.
目的
有效管理伤口疼痛对于伤口愈合至关重要。然而，伤口疼痛干预的结果基于主观措施，这在认知障碍患者中可能会出现问题。与伤口疼痛和伤口愈合相关的生物标志物的鉴定可用于更客观地评估伤口疼痛，并有助于开发精确的管理方案来减少伤口疼痛和促进伤口愈合。本范围综述旨在从伤口渗出物中确定伤口疼痛和伤口愈合的生物标志物，并描述不同的伤口采集方法以识别这些生物标志物。
方法
我们通过范围综述搜索了文献（PROSPERO 数据库注册号：CRD42018103843）。
搜索策略
通过 PubMed 数据库搜索探讨皮肤伤口疼痛、伤口愈合和生物分子之间关系的文章。纳入标准为报告原始数据、使用成人人体样本且以英文发表的文章。
发现
共检索到 21 篇文章：17 篇研究了与伤口愈合状态相关的伤口渗出物中的分子，4 篇报告了与伤口疼痛相关的分子。最常观察到的伤口疼痛生物标志物是促炎细胞因子；最常观察到的伤口愈合生物标志物是蛋白酶，包括基质金属蛋白酶家族中的蛋白酶。确定了 6 种伤口渗出液采集方法，以从伤口渗出液中提取潜在的伤口疼痛和伤口愈合生物标志物。
结论
这些结果可以指导未来的伤口渗出液研究，以验证这些伤口疼痛和伤口愈合生物标志物，并开发针对这些生物标志物的治疗方法，以减少伤口疼痛和促进伤口愈合。
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