Department of Pharmacology, Lovely Institute of Technology (Pharmacy), Lovely Professional University (LPU), Phagwara, Punjab, 144411, India.
Department of Pharmacy, Banasthali Vidyapith, Tonk, Rajasthan, 304022, India.
Appl Biochem Biotechnol. 2023 May;195(5):3384-3405. doi: 10.1007/s12010-022-04282-z. Epub 2023 Jan 3.
Taraxacum officinale play an important role in the prophylaxis and treatment of cardiovascular disease (CVD). Taraxacum officinale is proven as promising antioxidant in earlier studies and one of its constituent "cichoric acid" is shown to have vasorelaxant property. Therefore, present study mainly designed to investigate the cardioprotective effects of Taraxacum officinale against ischemia-reperfusion injury (I/R injury)-induced myocardial dysfunction in rats. This study not only explored the overall cardioprotective potential but also tried to explore its molecular mechanism using pharmacological inhibition via L-NAME and glibenclamide. Pretreatment of methanolic extract of Taraxacum officinale significantly attenuated (p < 0.001) increased levels of lactate dehydrogenase (LDH), creatine kinase (CK), infarct size, and thiobarbituric acid reactive substance (TBARS), while it increased the reduced levels of protein content, glutathione (GSH), and catalase (CAT) activity. Results showed that pretreatment with methanolic extract of Taraxacum officinale provides cardioprotection against I/R induced myocardial dysfunction, at least, may be mediated through the endogenous release of nitric oxide.
蒲公英在心血管疾病 (CVD) 的预防和治疗中起着重要作用。蒲公英在早期研究中被证明具有有前景的抗氧化作用，其成分之一“菊苣酸”具有血管舒张作用。因此，本研究主要旨在研究蒲公英对大鼠缺血再灌注损伤 (I/R 损伤) 诱导的心肌功能障碍的心脏保护作用。本研究不仅探索了整体心脏保护潜力，还试图通过 L-NAME 和格列本脲的药理学抑制来探索其分子机制。蒲公英的甲醇提取物预处理显著减弱（p<0.001）乳酸脱氢酶（LDH）、肌酸激酶（CK）、梗死面积和硫代巴比妥酸反应物质（TBARS）的升高水平，同时增加还原型蛋白含量、谷胱甘肽 (GSH) 和过氧化氢酶 (CAT) 活性的降低水平。结果表明，蒲公英的甲醇提取物预处理可提供对 I/R 诱导的心肌功能障碍的心脏保护作用，至少可能是通过内源性一氧化氮的释放介导的。
