Department of Breast Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, PR China.
Department of Breast Surgery, The Affiliated Cancer Hospital of Guangxi Medical University, Nanning, PR China.
Medicine (Baltimore). 2022 Dec 30;101(52):e32444. doi: 10.1097/MD.0000000000032444.
There is no evidence showing that the expression of procollagen C-endopeptidase enhancer (PCOLCE) is associated with human tumors, and pan-cancer analysis is not available. Based on public databases such as the cancer genome atlas, we investigated the potential role of PCOLCE expression in 33 different human tumors. PCOLCE expression in 11 tumors was significantly correlated with tumor prognosis and was a prognostic predictor for pancreatic adenocarcinoma, thymoma and CES. We also found that PCOLCE expression correlated with the immune microenvironment of tumors and the level of cancer-associated fibroblast infiltration. PCOLCE is a potential predictor of small molecule targeted drugs and immune checkpoint inhibitors. Finally, we found by enrichment analysis that PCOLCE localizes to extracellular structures and the extracellular matrix and exerts substantial effects on tumors through the PI3K-Akt and AGE-RAGE signaling pathways. We have a preliminary and relatively comprehensive understanding of the role of PCOLCE in various tumors.
没有证据表明前胶原 C 端肽酶增强子 (PCOLCE) 的表达与人类肿瘤有关，也没有泛癌分析。基于癌症基因组图谱等公共数据库，我们研究了 PCOLCE 表达在 33 种不同人类肿瘤中的潜在作用。在 11 种肿瘤中，PCOLCE 的表达与肿瘤预后显著相关，是胰腺腺癌、胸腺瘤和 CES 的预后预测因子。我们还发现 PCOLCE 的表达与肿瘤的免疫微环境和癌症相关成纤维细胞浸润水平相关。PCOLCE 是小分子靶向药物和免疫检查点抑制剂的潜在预测因子。最后，通过富集分析发现 PCOLCE 定位于细胞外结构和细胞外基质，并通过 PI3K-Akt 和 AGE-RAGE 信号通路对肿瘤产生重大影响。我们对 PCOLCE 在各种肿瘤中的作用有了初步的、相对全面的了解。
