Wang Jianping, Shang Peng
School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China; Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China.
Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, 518057, China; School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China; Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China.
Prog Biophys Mol Biol. 2023 Mar;178:91-102. doi: 10.1016/j.pbiomolbio.2022.12.007. Epub 2022 Dec 31.
Osteoporosis is a kind of bone diseases characterized by dynamic imbalance of bone formation and bone absorption, which is prone to fracture, and seriously endangers human health. At present, there is a lack of highly effective drugs for it, and the existing measures all have some side effects. In recent years, mesenchymal stem cell therapy has brought a certain hope for osteoporosis, while shortcomings such as homing difficulty and unstable therapeutic effects limit its application widely. Therefore, it is extremely urgent to find effective and reliable means/drugs for adjuvant stem cell therapy or develop new research techniques. It has been reported that static magnetic fields(SMFs) has a certain alleviating and therapeutic effect on varieties of bone diseases, also promotes the proliferation and osteogenic differentiation of mesenchymal stem cells derived from different tissues to a certain extent. Basing on the above background, this article focuses on the key words "static/constant magnetic field, mesenchymal stem cell, osteoporosis", combined literature and relevant contents were studied to look forward that SMFs has unique advantages in the treatment of osteoporosis with mesenchymal stem cells, which can be used as an application tool to promote the progress of stem cell therapy in clinical application.
骨质疏松症是一种以骨形成和骨吸收动态失衡为特征的骨疾病，易发生骨折，严重危害人类健康。目前，针对该疾病缺乏高效药物，现有治疗措施均存在一定副作用。近年来，间充质干细胞疗法给骨质疏松症带来了一定希望，然而归巢困难和治疗效果不稳定等缺点限制了其广泛应用。因此，寻找有效且可靠的辅助干细胞治疗手段/药物或开发新的研究技术迫在眉睫。据报道，静磁场对多种骨疾病具有一定的缓解和治疗作用，在一定程度上还能促进不同组织来源的间充质干细胞增殖和成骨分化。基于上述背景，本文围绕“静/恒磁场、间充质干细胞、骨质疏松症”等关键词，结合文献及相关内容进行研究，以期静磁场在间充质干细胞治疗骨质疏松症方面具有独特优势，可作为促进干细胞治疗临床应用进展的一种应用工具。
