Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Food and Drug Control Center Office, Derna, Libya.
Nat Prod Res. 2023 Nov-Dec;37(23):4038-4041. doi: 10.1080/14786419.2022.2164280. Epub 2023 Jan 3.
Herpes simplex virus (HSV) can infect millions of people worldwide causing mild to life-threating infections. The current study demonstrates the first comparative anti-HSV type 1 activity and phytochemical investigation of and collected from Egypt and Libya. Liquid chromatography/mass spectrometry (LC/MS) analysis allowed the identification of 56 and 38 compounds in the Egyptian and Libyan ethanolic extracts, respectively, in addition to 46 and 50 compounds in the Egyptian and Libyan ethanolic extracts, respectively. Gas chromatography/mass spectrometry (GC/MS) analysis of their corresponding essential oils revealed the presence of 15, 17, 17 and 8 compounds in Egyptian and Libyan and respectively. The major chemical classes of the identified compounds were phenolic acids, flavonoids and oxygenated monoterpenes. Evaluation of the anti-HSV1 activities of the studied extracts showed that the Egyptian ethanolic extracts were the most potent extract with more than 200-fold reduction in the viral PFU.
单纯疱疹病毒（HSV）可感染全球数百万人，引起轻度至危及生命的感染。本研究首次对从埃及和利比亚收集的 和 进行了抗 HSV-1 活性和植物化学物质的比较研究。液相色谱/质谱联用（LC/MS）分析分别鉴定了埃及和利比亚 乙醇提取物中的 56 种和 38 种化合物，此外，埃及和利比亚 乙醇提取物中分别鉴定了 46 种和 50 种化合物。气相色谱/质谱联用（GC/MS）分析其相应的精油显示，埃及和利比亚的 和 中分别存在 15、17、17 和 8 种化合物。鉴定化合物的主要化学类为酚酸、类黄酮和含氧单萜。对研究提取物抗 HSV1 活性的评价表明，埃及 乙醇提取物是最有效的提取物，病毒 PFU 减少了 200 多倍。
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