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Genetically proxied TYK2 inhibition is associated with reduced sarcoidosis susceptibility.

作者信息

Zhao Sizheng Steven, Barton Anne, Bowes John

机构信息

Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Science, School of Biological Sciences, Faculty of Biological Medicine and Health, The University of Manchester, Manchester, UK

Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

出版信息

Ann Rheum Dis. 2023 Mar;82(3):445-446. doi: 10.1136/ard-2022-223513. Epub 2022 Dec 9.

DOI:10.1136/ard-2022-223513
PMID:36600188
Abstract
摘要

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Genetically proxied TYK2 inhibition is associated with reduced sarcoidosis susceptibility.基因代理的酪氨酸激酶2（TYK2）抑制与结节病易感性降低相关。
Ann Rheum Dis. 2023 Mar;82(3):445-446. doi: 10.1136/ard-2022-223513. Epub 2022 Dec 9.
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Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases.孟德尔随机化和临床试验证据支持 TYK2 抑制作为自身免疫性疾病的治疗靶点。
EBioMedicine. 2023 Mar;89:104488. doi: 10.1016/j.ebiom.2023.104488. Epub 2023 Feb 24.
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A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis.酪氨酸激酶2（Tyk2）的单核苷酸多态性控制实验性自身免疫性脑脊髓炎的易感性。
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Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis.酪氨酸激酶2（TYK2）基因多态性与自身免疫性风湿性疾病易感性的关联：一项荟萃分析。
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Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies.免疫相关基因变异的基因分型确定酪氨酸激酶2（TYK2）是特发性炎性肌病的一个新的相关基因座。
Ann Rheum Dis. 2014 Sep;73(9):1750-2. doi: 10.1136/annrheumdis-2014-205440. Epub 2014 May 7.
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Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.复制分析确定酪氨酸激酶2（TYK2）为多发性硬化症的易感因素。
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Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population.马来西亚人群中TYK2和STAT3基因与克罗恩病之间不存在关联。
Genet Mol Res. 2013 Jan 24;12(1):167-74. doi: 10.4238/2013.January.24.9.
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Lack of association of TYK2 gene polymorphisms in Chinese patients with systemic lupus erythematosus.中国系统性红斑狼疮患者中TYK2基因多态性的关联性缺失
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GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population.GLIS3和TYK2单核苷酸多态性与中国汉族人群皮肌炎/多发性肌炎无关。
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TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.TYK2 rs34536443 多态性与子宫内膜异位症相关不孕易感性降低相关。
Hum Immunol. 2013 Jan;74(1):93-7. doi: 10.1016/j.humimm.2012.09.007. Epub 2012 Sep 20.

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Nat Commun. 2025 Mar 12;16(1):2481. doi: 10.1038/s41467-025-57829-z.
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