Sharma Neeraj, Abdulkhalek Samer
Department of Nephrology, University of Southern California, Los Angeles, USA.
Department of Nephrology, University of Southern California Keck School of Medicine, Los Angeles, USA.
Cureus. 2022 Nov 29;14(11):e32021. doi: 10.7759/cureus.32021. eCollection 2022 Nov.
John Cunningham (JC) polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of polyomavirus-associated nephropathy (PVAN). Although BK polyomavirus (BKPyV) is a relatively proven common infection post kidney transplantation, JC polyomavirus (JCPyV) infection and its impact on graft function have been less studied. Here, we report a case of a deceased donor kidney transplant recipient who was diagnosed with allograft dysfunction due to JC-PVAN six years after transplantation. JC viremia resolved after a reduction in immunosuppression and treatment with intravenous immunoglobulin (IVIG); however, she developed an acute cellular rejection with moderate fibrosis resulting in chronic kidney disease in the allograft.
约翰·坎宁安（JC）多瘤病毒相关性肾病（JC-PVAN）是多瘤病毒相关性肾病（PVAN）的一种罕见病因。尽管BK多瘤病毒（BKPyV）是肾移植后相对已证实的常见感染源，但JC多瘤病毒（JCPyV）感染及其对移植肾功能的影响研究较少。在此，我们报告一例尸体供肾移植受者，该患者在移植后六年因JC-PVAN被诊断为移植肾功能障碍。在免疫抑制减少并接受静脉注射免疫球蛋白（IVIG）治疗后，JC病毒血症得到缓解；然而，她发生了伴有中度纤维化的急性细胞排斥反应，导致移植肾出现慢性肾病。
