Louis Mariam, Patel Bijal, Prange Edward, Celso Brian
Pulmonology, University of Florida College of Medicine-Jacksonville, Jacksonville, USA.
Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, USA.
Cureus. 2022 Nov 30;14(11):e32052. doi: 10.7759/cureus.32052. eCollection 2022 Nov.
Background This study aimed to investigate the actual weight change documented as a goal of treatment after patients were newly diagnosed with obstructive sleep apnea (OSA). We hypothesized that patients with OSA and classified as overweight and obese based on BMI would fail to achieve significant weight loss over a two- to five-year period. Methodology This retrospective review included adults aged 18 years or older who were newly diagnosed with OSA in 2015, as indicated by a full nocturnal polysomnogram and using the 4% rule for the definition of hypopnea. Data collected were between January 01, 2015, and December 31, 2020. Patients received either usual care for weight reduction or bariatric surgery to assess the overall weight loss and identify barriers. Statistical analysis included independent t-tests, Mann-Whitney U tests and related samples McNemar change statistics, Cox proportional hazards regression, and Kaplan-Meier curves to analyze age, gender, ethnicity, and weight differences between usual care and bariatric surgery groups. Results The number of participants included for usual care and bariatric surgery was 100 and 24, respectively. Over five years, 87% of the usual care patients remained in the same BMI classification, 7% lowered their classification, and 6% raised theirs. For usual care patients, the average net weight per individual of 2.19 kg gained represented a 1.96% weight change. Bariatric patients lost an average net weight of 30.40 kg (22.39%). Cox proportional hazards regression showed that the overall model fit was statistically significant (χ = 55.40, degrees of freedom [df] = 9, and -value < 0.001). The significant variables were time-dependent weight change and ethnicity. The Kaplan-Meier curve revealed that weight loss reduced over time in treatment. Conclusions This study confirmed that despite the direction to lose weight, only 7% of OSA patients lowered their BMI classification. Patient instruction and provider-driven weight loss strategies seem equally ineffective to achieve sustained weight reduction among high-risk groups. More research is needed to investigate optimal strategies that include interprofessional collaborative practices for sustained weight loss.
背景 本研究旨在调查新诊断为阻塞性睡眠呼吸暂停(OSA)的患者记录的治疗目标中的实际体重变化。我们假设,根据BMI被分类为超重和肥胖的OSA患者在两到五年内无法实现显著的体重减轻。方法 这项回顾性研究纳入了2015年新诊断为OSA的18岁及以上成年人,全夜多导睡眠图显示符合条件,并采用4%规则定义呼吸暂停低通气。收集的数据时间为2015年1月1日至2020年12月31日。患者接受常规减肥护理或减肥手术,以评估总体体重减轻情况并识别障碍因素。统计分析包括独立t检验、曼-惠特尼U检验和相关样本的麦克尼马尔变化统计、Cox比例风险回归以及Kaplan-Meier曲线,以分析常规护理组和减肥手术组之间的年龄、性别、种族和体重差异。结果 接受常规护理和减肥手术的参与者人数分别为100人和24人。在五年期间,87%的常规护理患者BMI分类保持不变,7%的患者分类降低,6%的患者分类升高。对于常规护理患者,个体平均净增重2.19千克,体重变化为1.96%。减肥手术患者平均净减重30.40千克(22.39%)。Cox比例风险回归显示,总体模型拟合具有统计学意义(χ = 55.40,自由度[df] = 9,P值<0.001)。显著变量是随时间变化的体重变化和种族。Kaplan-Meier曲线显示,治疗过程中体重减轻随时间减少。结论 本研究证实,尽管有减肥的指导,但只有7%的OSA患者降低了BMI分类。患者指导和医疗服务提供者驱动的减肥策略在高危人群中实现持续体重减轻方面似乎同样无效。需要更多研究来调查包括跨专业协作实践在内的实现持续体重减轻的最佳策略。