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探索左炔诺孕酮宫内节育系统(LNG-IUS)作为紧急避孕(EC)方法的作用。

Exploring the Role of Levonorgestrel Intrauterine System (LNG-IUS) as a Method of Emergency Contraception (EC).

作者信息

Kumari Snigdha, Sarkar Avir, Kulshreshtha Anshul, Zangmo Rinchen, Roy K K

机构信息

Obstetrics and Gynecology, Post Graduate Institute of Medical Education and Research, Chandigarh, IND.

Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, IND.

出版信息

Cureus. 2022 Nov 28;14(11):e31959. doi: 10.7759/cureus.31959. eCollection 2022 Nov.

DOI:10.7759/cureus.31959
PMID:36600871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9800030/
Abstract

Copper T 380-A (CuT380A) intrauterine device (IUD) has been an effective method of emergency contraception (EC). Levonorgestrel intrauterine system (LNG-IUS) has not been approved by the Food and Drug Association for EC till now. There are few studies that provide data regarding the efficacy of LNG-IUS as EC. This systematic review tried to explore the efficacy of LNG-IUS in preventing accidental pregnancies up to five days of unprotected intercourse. A systematic review of the published studies on the use of LNG-IUS as EC was done. All randomized trials, prospective cohorts, retrospective cohorts. and case-control study designs pertaining to this topic were included in this review. Abstracts were retrieved and reviewed by two authors independently. Variables pertaining to socio-demographic parameters, EC use-related variables (reason for use, frequency, time elapsed since coitus), and those associated with sexual habits were selected and recorded. A total of six articles were rendered for the review. High school students and those attending college accounted for 36.8%-51.8% of the study population. Data on the reason for seeking EC showed noncompliance to routine contraception as the most common reason, followed by failure of withdrawal method, breach of barrier contraception, and unplanned intercourse. With a negligible failure rate, LNG-IUS seemed to be a good alternative to the existing copper EC. Considering the plethora of noncontraceptive benefits associated, LNG-IUS can be safely provided as an option of EC in the cafeteria approach within five days of unprotected intercourse.

摘要

铜T 380-A(CuT380A)宫内节育器(IUD)一直是一种有效的紧急避孕(EC)方法。左炔诺孕酮宫内节育系统(LNG-IUS)至今尚未获得美国食品药品监督管理局批准用于紧急避孕。很少有研究提供关于LNG-IUS作为紧急避孕有效性的数据。本系统评价试图探讨LNG-IUS在预防无保护性交后五天内意外妊娠的有效性。对已发表的关于使用LNG-IUS作为紧急避孕的研究进行了系统评价。所有关于该主题的随机试验、前瞻性队列研究、回顾性队列研究和病例对照研究设计均纳入本评价。两位作者独立检索和审查摘要。选择并记录与社会人口统计学参数、紧急避孕使用相关变量(使用原因、频率、性交后经过的时间)以及与性行为习惯相关的变量。总共筛选了六篇文章进行综述。高中生和大学生占研究人群的36.8%-51.8%。寻求紧急避孕原因的数据显示,不遵守常规避孕是最常见的原因,其次是撤退法失败、屏障避孕失败和意外性交。LNG-IUS的失败率可忽略不计,似乎是现有含铜紧急避孕方法的一个很好替代方案。考虑到与之相关的大量非避孕益处,在无保护性交后五天内的自助式服务中,LNG-IUS可以作为紧急避孕的一种选择安全提供。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/852a/9800030/a37bede20972/cureus-0014-00000031959-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/852a/9800030/6f60d285ae84/cureus-0014-00000031959-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/852a/9800030/4895057a24d4/cureus-0014-00000031959-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/852a/9800030/a37bede20972/cureus-0014-00000031959-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/852a/9800030/6f60d285ae84/cureus-0014-00000031959-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/852a/9800030/4895057a24d4/cureus-0014-00000031959-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/852a/9800030/a37bede20972/cureus-0014-00000031959-i03.jpg

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本文引用的文献

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Obstet Gynecol. 2021 Jul 1;138(1):79-84. doi: 10.1097/AOG.0000000000004433.
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The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.
《PRISMA 2020声明:报告系统评价的更新指南》
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Levonorgestrel vs. Copper Intrauterine Devices for Emergency Contraception.左炔诺孕酮与铜宫内节育器用于紧急避孕。
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One-year continuation of copper or levonorgestrel intrauterine devices initiated at the time of emergency contraception.在紧急避孕时开始使用的铜宫内节育器或左炔诺孕酮宫内节育器的一年续用。
Contraception. 2017 Aug;96(2):99-105. doi: 10.1016/j.contraception.2017.05.012. Epub 2017 Jun 5.
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U.S. Medical Eligibility Criteria for Contraceptive Use, 2016.美国避孕方法医学适用标准,2016 年版。
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