Panchal Pooja D, Ravalia Anal, Rana Ritu, Puthussery Shuby, Vaze Gauri, Mavlankar Dileep, Menon Kavitha
Symbiosis Institute of Health Sciences (SIHS), Symbiosis International (Deemed University) (SIU), Lavale, Pune, Maharashtra, India.
Indian Institute of Public Health-Gandhinagar, Gujarat, India.
Curr Dev Nutr. 2022 Sep 12;6(12):nzac134. doi: 10.1093/cdn/nzac134. eCollection 2022 Dec.
The UN Sustainable Development Goal aims at a 50% reduction of anemia in women of reproductive age (WRA) by 2030. Several nutrition-specific and sensitive interventions are targeted across low- and middle-income countries (LMICs) to reduce anemia.
In this meta-review we comprehensively assessed the effectiveness of nutrition-specific and -sensitive interventions on hemoglobin (Hb) and serum ferritin (SF) concentrations and the prevalence of iron deficiency and anemia among WRA, pregnant women, and lactating women from LMICs.
The preparation of the present meta-review followed a double-blinded synthesis process with 3 stages: screening, quality appraisal, and data extraction in Eppi Reviewer. A comprehensive search was performed for systematic reviews (SRs) published between January 2000 and May 2022 using 21 international, national, and regional databases. The methodological quality appraisal of included studies was conducted using the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) checklist.
A total of 23 SRs evaluated the effects of various nutrition-specific interventions included in the final synthesis. The included SRs included analyses of nutrition-specific interventions such as supplementation of the nutrients iron ( = 7), iron and folic acid ( = 4), vitamin A ( = 3), calcium ( = 2), multiple micronutrients ( = 7), and intravenous iron sucrose ( = 2). Also, SRs on fortification of nutrients included multiple micronutrients ( = 6), iron and folic acid ( = 4), and iron ( = 4). Of the 23 SRs, 22 were of high quality. Iron with or without folic acid supplementation and fortification and vitamin A supplementation consistently showed positive effects on either reduction in the prevalence of anemia or iron deficiency and improving the Hb or SF concentrations in WRA and pregnant women from LMICs.
The comprehensive meta-review reported the beneficial effects of iron with or without folic acid, multiple micronutrient supplementation/fortification, and vitamin A supplementation in reducing the prevalence of anemia or iron deficiency and increasing Hb or SF concentrations in WRA from LMICs.
联合国可持续发展目标旨在到2030年将育龄妇女贫血率降低50%。低收入和中等收入国家（LMICs）针对几种特定营养和敏感干预措施来减少贫血。
在本荟萃综述中，我们全面评估了特定营养和敏感干预措施对低收入和中等收入国家育龄妇女、孕妇和哺乳期妇女血红蛋白（Hb）和血清铁蛋白（SF）浓度以及缺铁和贫血患病率的有效性。
本荟萃综述的编制遵循三阶段双盲综合过程：在Eppi Reviewer中进行筛选、质量评估和数据提取。使用21个国际、国家和区域数据库，对2000年1月至2022年5月发表的系统评价（SRs）进行了全面检索。使用评估系统评价方法学质量（AMSTAR）清单对纳入研究进行方法学质量评估。
共有23项系统评价评估了最终综合分析中纳入的各种特定营养干预措施的效果。纳入的系统评价包括对特定营养干预措施的分析，如补充铁（n = 7）、铁和叶酸（n = 4）、维生素A（n = 3）、钙（n = 2）、多种微量营养素（n = 7）和静脉注射蔗糖铁（n = 2）。此外，关于营养素强化的系统评价包括多种微量营养素（n = 6）、铁和叶酸（n = 4）以及铁（n = 4）。在23项系统评价中，22项质量较高。补充有或没有叶酸的铁以及强化铁和补充维生素A对降低低收入和中等收入国家育龄妇女和孕妇的贫血患病率或缺铁率以及提高血红蛋白或血清铁蛋白浓度始终显示出积极效果。
综合荟萃综述报告了补充有或没有叶酸的铁、多种微量营养素补充/强化以及补充维生素A在降低低收入和中等收入国家育龄妇女贫血患病率或缺铁率以及提高血红蛋白或血清铁蛋白浓度方面的有益效果。
