Zhang Beibei, Luo Junfei, Fang Yewen
Institute of Mass Spectrometry, School of Materials Science and Chemical Engineering, Ningbo University, No. 818 Fenghua Road, Ningbo 315211, China.
School of Materials and Chemical Engineering, Ningbo University of Technology, No. 201 Fenghua Road, Ningbo 315211, China.
Org Biomol Chem. 2023 Jan 25;21(4):732-737. doi: 10.1039/d2ob02155b.
Herein, using a single-electron-transfer reduction-based radical-polar crossover process as a strategy, protocols dealing with the preparation of functionalized alkynylcyclopropanes have been successfully developed the reactions of 1,3-enynes with alkyl radicals. In addition to redox-neutral photocatalysis, nickel catalysis with zinc as the reductant is also an alternative to enable reactions of 1,3-enynes with redox-active -hydroxyphthalimide esters. The synthetic application of alkynylcyclopropane has also been demonstrated.
在此，以基于单电子转移还原的自由基-极性交叉过程为策略，成功开发了处理功能化炔基环丙烷制备的方案，即1,3-烯炔与烷基自由基的反应。除了氧化还原中性光催化外，以锌作为还原剂的镍催化也是实现1,3-烯炔与氧化还原活性的α-羟基邻苯二甲酰亚胺酯反应的一种替代方法。炔基环丙烷的合成应用也得到了证明。
