Wang Yi, Deng Jiachen, Ressler Andrew J, Lin Song
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
Org Lett. 2024 Jan 12;26(1):116-121. doi: 10.1021/acs.orglett.3c03722. Epub 2023 Dec 29.
Compared with flat aromatic scaffolds, three-dimensional aliphatic ring systems feature high structural complexity and topological diversity and, thus, have received increasing attention in drug discovery. Herein, we describe a mild and general electrochemical method for the modular synthesis of structurally distinct cyclic compounds, including monocyclic alkanes, benzo-fused ring systems, and spirocycles, from readily available alkenes and alkyl halides via a radical-polar crossover mechanism.
与平面芳香骨架相比，三维脂肪族环系统具有高度的结构复杂性和拓扑多样性，因此在药物发现中受到越来越多的关注。在此，我们描述了一种温和且通用的电化学方法，用于通过自由基-极性交叉机制从易得的烯烃和卤代烃模块化合成结构各异的环状化合物，包括单环烷烃、苯并稠环系统和螺环化合物。
