Dutta Nilakshi, Dutta Bidyutjyoti, Dutta Apurba, Sarma Bipul, Sarma Diganta
Department of Chemistry, Dibrugarh University, Dibrugarh-786004, Assam, India.
Department of Chemistry, DHSK College, Dibrugarh-786001, Assam, India.
Org Biomol Chem. 2023 Jan 25;21(4):748-753. doi: 10.1039/d2ob02085h.
An efficient and simple copper catalytic system has been developed for the synthesis of medicinally important 2-substituted quinazoline-4(3)-ones from 2-aminobenzonitrile and benzyl alcohol derivatives and additionally 2-substituted quinazolines from 2-aminobenzylamine and benzaldehyde derivatives. Mild oxidant HO was utilized, providing excellent product yields. The molecular structure of one of the compounds was substantiated through SC-XRD. The versatility of the protocol was demonstrated through gram-scale syntheses.
