Diri Doried, Alasaad Hakam, Muhammed Hussain, Ibrahim Jaber
AL Asad University Hospital, Damascus, Syria.
AL Asad University Hospital, Damascus, Syria.
Int J Surg Case Rep. 2023 Jan;102:107861. doi: 10.1016/j.ijscr.2022.107861. Epub 2022 Dec 31.
Core decompression is a well-known modality for treating the early stages of avascular necrosis of the femoral head (AVN), however, several methods have been suggested to augment this procedure and improve the outcomes.
A 52 male was diagnosed with a stage I AVN of the femoral head and treated with core decompression (CD) and injection of adipose-derived mesenchymal stem cells (AD-MSCs). The MRI showed full healing of the lesion after 3 months with significant clinical and functional improvement.
AD-MSCs could have the same capabilities as bone marrow-derived stem cells with many advantages, implantation of AD-MSCs in orthopedics and as an augmentation of core decompression has been tried before, but no clear guidelines nor methods of application are well established in the literature.
Implantation of AD-MSCs with Core decompression could be an effective modality to treat osteonecrosis of the femoral head in pre-collapse stages, however, we need bigger clinical studies to determine the actual effectiveness of this method.
核心减压是治疗股骨头缺血性坏死（AVN）早期阶段的一种知名方法，然而，已有多种方法被提出以增强该手术并改善治疗效果。
一名52岁男性被诊断为股骨头I期AVN，接受了核心减压（CD）及脂肪源性间充质干细胞（AD-MSCs）注射治疗。3个月后MRI显示病变完全愈合，临床及功能有显著改善。
AD-MSCs可能具有与骨髓源性干细胞相同的能力且有诸多优势，此前已尝试将AD-MSCs植入骨科并作为核心减压的增强手段，但文献中尚未建立明确的指南及应用方法。
核心减压联合AD-MSCs植入可能是治疗股骨头坏死塌陷前期的一种有效方法，然而，我们需要更大规模的临床研究来确定该方法的实际有效性。
