运动时戴口罩试验（MERIT）：一项交叉随机对照研究。

Face masks while exercising trial (MERIT): a cross-over randomised controlled study.

机构信息

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

出版信息

BMJ Open. 2023 Jan 5;13(1):e063014. doi: 10.1136/bmjopen-2022-063014.

DOI:10.1136/bmjopen-2022-063014

PMID:36604128

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9827243/

Abstract

OBJECTIVES

Physical exertion is a high-risk activity for aerosol emission of respiratory pathogens. We aimed to determine the safety and tolerability of healthy young adults wearing different types of face mask during moderate-to-high intensity exercise.

DESIGN

Cross-over randomised controlled study, completed between June 2021 and January 2022.

PARTICIPANTS

Volunteers aged 18-35 years, who exercised regularly and had no significant pre-existing health conditions.

INTERVENTIONS

Comparison of wearing a surgical, cloth and filtering face piece (FFP3) mask to no mask during 4×15 min bouts of exercise. Exercise was running outdoors or indoor rowing at moderate-to-high intensity, with consistency of distance travelled between bouts confirmed using a smartphone application (Strava). Each participant completed each bout in random order.

OUTCOMES

The primary outcome was change in oxygen saturations. Secondary outcomes were change in heart rate, perceived impact of face mask wearing during exercise and willingness to wear a face mask for future exercise.

RESULTS

All 72 volunteers (mean age 23.9) completed the study. Changes in oxygen saturations did not exceed the prespecified non-inferiority margin (2% difference) with any mask type compared with no mask. At the end of exercise, the estimated average difference in oxygen saturations for cloth mask was -0.07% (95% CI -0.39% to 0.25%), for surgical 0.28% (-0.04% to 0.60%) and for FFP3 -0.21% (-0.53% to 0.11%). The corresponding estimated average difference in heart rate for cloth mask was -1.20 bpm (95% CI -4.56 to 2.15), for surgical 0.36 bpm (95% CI -3.01 to 3.73) and for FFP3 0.52 bpm (95% CI -2.85 to 3.89). Wearing a face mask caused additional symptoms such as breathlessness (n=13, 18%) and dizziness (n=7, 10%). 33 participants broadly supported face mask wearing during exercise, particularly indoors, but 22 were opposed.

CONCLUSION

This study adds to previous findings (mostly from non-randomised studies) that exercising at moderate-to-high intensity wearing a face mask appears to be safe in healthy, young adults.

TRIAL REGISTRATION NUMBER

NCT04932226.

摘要

目的

体力活动是呼吸道病原体气溶胶排放的高危活动。我们旨在确定健康的年轻成年人在进行中高强度运动时佩戴不同类型口罩的安全性和耐受性。

设计

交叉随机对照研究，于 2021 年 6 月至 2022 年 1 月完成。

参与者

年龄在 18-35 岁之间、经常锻炼且无明显既往健康状况的志愿者。

干预措施

比较在 4 次 15 分钟的运动中佩戴外科口罩、布口罩和过滤面罩（FFP3）与不戴口罩的情况。运动在户外或室内进行，强度为中高强度，使用智能手机应用程序（Strava）确认各次运动之间的行驶距离一致性。每位参与者以随机顺序完成各次运动。

主要结局

氧饱和度的变化。次要结局包括运动时戴口罩对心率的影响、运动时戴口罩的影响感知以及未来运动时戴口罩的意愿。

结果

所有 72 名志愿者（平均年龄 23.9 岁）均完成了研究。与不戴口罩相比，任何口罩类型的氧饱和度变化均未超过预设的非劣效性边界（2%的差异）。运动结束时，布口罩的估计平均血氧饱和度差异为-0.07%（95%CI-0.39%至 0.25%），外科口罩为 0.28%（95%CI-0.04%至 0.60%），FFP3 为-0.21%（95%CI-0.53%至 0.11%）。布口罩的估计平均心率差异为-1.20 bpm（95%CI-4.56 至 2.15），外科口罩为 0.36 bpm（95%CI-3.01 至 3.73），FFP3 为 0.52 bpm（95%CI-2.85 至 3.89）。戴口罩会导致额外的症状，如呼吸困难（13 名，18%）和头晕（7 名，10%）。33 名参与者普遍支持在运动时戴口罩，尤其是在室内，但也有 22 名参与者反对。