DU Wei, Wang Wen-Ping, Cao Ying
Liaoning University of Traditional Chinese Medicine Shenyang 110847, China.
the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Shenyang 110032, China.
Zhongguo Zhong Yao Za Zhi. 2022 Dec;47(23):6297-6307. doi: 10.19540/j.cnki.cjcmm.20220725.501.
Although targeted therapy and immunotherapy will become the trend of systematic therapy for tumor in the future, radiotherapy and chemotherapy are still regarded as one of the main means to treat cancer due to their low price and wide application. The toxic and side effects of radiotherapy and chemotherapy can limit the therapeutic effect and affect the body immunity, which is very difficult to deal with by modern medical means, and in this process, patients are prone to develop resistance to the application of radiotherapy and chemotherapy, which makes it difficult to implement follow-up treatment, leading to disease progression and ultimately affecting the prognosis of patients. In recent years, a large number of traditional Chinese medicine(TCM)-related clinical studies have found that classical prescriptions and non-classical prescriptions can markedly alleviate the toxic and side effects caused by radiotherapy and chemotherapy, with clear and significant efficacy, and to some extent, they can improve the quality of life and prolong the survival period of patients. Therefore, TCM decoction may provide new opportunities for intervening in the refractory and high-incidence toxic and side effects. To further explore the application of classical prescriptions and non-classical prescriptions in tumor, this study reviewed the mechanism of toxic and side effects caused by radiotherapy and chemotherapy, the mechanism of classical prescriptions and non-classical prescriptions in the treatment of toxic and side effects, and the classical prescriptions and non-classical prescriptions used for treating common toxic and side effects in recent five years. This study was expected to promote the application and development of classical prescriptions and non-classical prescriptions in the field of cancer treatment by systematically summarizing their research progress in the prevention and treatment of toxic and side effects caused by radiotherapy and chemotherapy.
虽然靶向治疗和免疫治疗将成为未来肿瘤系统治疗的趋势，但放疗和化疗因其价格低廉、应用广泛，仍被视为治疗癌症的主要手段之一。放化疗的毒副作用会限制治疗效果并影响机体免疫力，这是现代医学手段很难应对的，在此过程中，患者容易对放化疗产生耐药性，导致后续治疗难以实施，进而使病情进展，最终影响患者预后。近年来，大量中医药相关临床研究发现，经典方剂和非经典方剂能显著减轻放化疗所致的毒副作用，疗效确切且显著，在一定程度上还能提高患者生活质量、延长生存期。因此，中药汤剂可能为难治性、高发性毒副作用的干预提供新契机。为进一步探讨经典方剂和非经典方剂在肿瘤治疗中的应用，本研究综述了放化疗所致毒副作用的机制、经典方剂和非经典方剂治疗毒副作用的机制以及近五年用于治疗常见毒副作用的经典方剂和非经典方剂。本研究旨在通过系统总结经典方剂和非经典方剂在防治放化疗毒副作用方面的研究进展，推动其在癌症治疗领域的应用与发展。
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