Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
Department of Gastroenterology, 36635China-Japan Friendship Hospital, Beijing, China.
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338221150322. doi: 10.1177/15330338221150322.
Gastrointestinal cancer is one of the most malignant tumors with high morbidity and mortality, especially colorectal cancer, which has become the second leading cause of cancer-related deaths worldwide. Targeted drug treatment and precise endoscopic resection can significantly improve the overall survival rate and greatly extend the life span. Promising biomedical applications of hydrogels would represent hopeful therapeutic alternatives for patients with different kinds of diseases, particularly providing precise therapy for cancer patients. Although the intersection field of material science and biomedical science has made tremendous advances, major challenges remain. In this review, the application of hydrogel-based technology in cancer precision medicine is the focus of attention, which is the development trend of multidisciplinary cooperation in the future. First, we provide the current clinical landscape of hydrogel applications, and then we highlight precision oncology, including personalized drug treatment and accurate endoscopic intervention. Finally, we discuss major challenges for their clinical translation that have not yet been overcome and future perspectives on cancer precision medicine.
胃肠道癌症是发病率和死亡率最高的恶性肿瘤之一，尤其是结直肠癌，已成为全球癌症相关死亡的第二大主要原因。靶向药物治疗和精确的内镜切除可以显著提高总生存率，大大延长患者的寿命。水凝胶在生物医学方面具有广阔的应用前景，为不同疾病的患者提供了有希望的治疗选择，特别是为癌症患者提供了精确的治疗。尽管材料科学和生物医学科学的交叉领域已经取得了巨大的进展，但仍存在重大挑战。在这篇综述中，我们关注的重点是基于水凝胶的技术在癌症精准医学中的应用，这是未来多学科合作的发展趋势。首先，我们提供了水凝胶应用的当前临床现状，然后重点介绍了精准肿瘤学，包括个性化药物治疗和精确的内镜干预。最后，我们讨论了其尚未克服的临床转化的主要挑战以及癌症精准医学的未来展望。
