Yu Zhiqiang, Xu Quan, Dong Chenbo, Lee Su Seong, Gao Liqian, Li Yiwen, D'Ortenzio Mathew, Wu Jun
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, 138669, Singapore.
Curr Pharm Des. 2015;21(29):4342-54. doi: 10.2174/1381612821666150901104821.
Molecular hydrogels have been widely explored in various biomedical applications, such as cell culture, tissue engineering and drug delivery. Peptide-based hydrogel nanoparticles represent a promising alternative to current drug delivery approaches and cell carriers for tissue engineering, due to their encapsulation stability, water solubility and biocompatibility. This review focuses on recent advances in the use of self-assembling peptide nanogels for applications in drug delivery. We firstly introduce a self-assembly mechanism for small molecules used in the peptide hydrogel, and then describe recent methods for controlling the assembly of molecular hydrogelations. A particular emphasis is placed on recent advances in the use of different types of peptide hydrogels as drug delivery carriers. Lastly, the current challenges and future perspectives for self-assembling peptide hydrogels in drug delivery applications are discussed.
分子水凝胶已在各种生物医学应用中得到广泛探索，如细胞培养、组织工程和药物递送。基于肽的水凝胶纳米颗粒由于其包封稳定性、水溶性和生物相容性，是目前药物递送方法和组织工程细胞载体的一种有前途的替代物。本综述重点介绍了自组装肽纳米凝胶在药物递送应用中的最新进展。我们首先介绍了肽水凝胶中使用的小分子的自组装机制，然后描述了控制分子水凝胶化组装的最新方法。特别强调了使用不同类型的肽水凝胶作为药物递送载体的最新进展。最后，讨论了自组装肽水凝胶在药物递送应用中的当前挑战和未来前景。
