重新审视胎儿肝脏造血：一种预制等级结构。
Fetal liver hematopoiesis revisited: a precast hierarchy.
作者信息
Azzoni Emanuele, Fantin Alessandro
机构信息
School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
University of Milan, Department of Biosciences, Milan, Italy.
出版信息
Nat Cardiovasc Res. 2022 Oct;1:872-873. doi: 10.1038/s44161-022-00142-5. Epub 2022 Oct 10.
Abstract
Late fetal liver hematopoiesis was thought to primarily rely on hematopoietic stem cells (HSCs). Using new genetic-tracing tools, a study shows that EVI1-positive HSCs mainly undergo expansion in the fetal liver, while differentiated blood cell production depends on HSC-independent intermediate hematopoietic progenitors.
摘要
晚期胎儿肝脏造血被认为主要依赖于造血干细胞（HSC）。一项研究使用新的基因追踪工具表明，EVI1阳性造血干细胞主要在胎儿肝脏中进行扩增，而分化血细胞的产生则依赖于不依赖造血干细胞的中间造血祖细胞。
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