催化剂控制的镍催化苯并咪唑与烯烃的分子内 - 选择性C-H环化反应
Catalyst-Controlled Nickel-Catalyzed Intramolecular -Selective C-H Cyclization of Benzimidazoles with Alkenes.
作者信息
Liu Zi-Jian, Li Jiang-Fei, Zhang Feng-Ping, Xu Xue-Tao, Ye Mengchun
机构信息
School of Biotechnology and Health Science, Wuyi University, Jiangmen, Guangdong 529020, China.
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
出版信息
Org Lett. 2023 Jan 20;25(2):353-357. doi: 10.1021/acs.orglett.2c04012. Epub 2023 Jan 6.
Compared with the widely explored -selective C-H cyclization, transition metal-catalyzed -selective C-H cyclization of benzimidazoles with alkenes has been a formidable challenge. Previous efforts mainly rely on substrate-controlled methods, rendering the product complexity restricted. Herein we report a catalyst-controlled method to facilitate -cyclization, in which a bulky -heterocyclic carbene ligand and BuOK base-enabled Ni-Al bimetallic catalyst prove critical to the selectivity.
与广泛研究的 - 选择性C - H环化相比，过渡金属催化的苯并咪唑与烯烃的 - 选择性C - H环化一直是一项艰巨的挑战。以往的努力主要依赖于底物控制的方法，使得产物的复杂性受到限制。在此，我们报道了一种促进 - 环化的催化剂控制方法，其中一种大位阻的 - 杂环卡宾配体和BuOK碱促进的Ni - Al双金属催化剂对 选择性至关重要。
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