手性镍-铝双金属催化的吲哚与烯烃的 exo-选择性 C-H 环化反应。
Enantioselective Ni-Al Bimetallic Catalyzed exo-Selective C-H Cyclization of Imidazoles with Alkenes.
机构信息
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry , Nankai University , Tianjin 300071 , China.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Nankai University , Tianjin 300071 , China.
出版信息
J Am Chem Soc. 2018 Apr 25;140(16):5360-5364. doi: 10.1021/jacs.8b02547. Epub 2018 Apr 16.
A Ni-Al bimetallic catalyzed enantioselective C-H exo-selective cyclization of imidazoles with alkenes has been developed. A series of bi- or polycyclic imidazoles with β-stereocenter were obtained in up to 98% yield and >99% ee. The bifunctional SPO ligand-promoted bimetallic catalysis proved to be critical to this challenging stereocontrol.
发展了一种 Ni-Al 双金属催化的具有对映选择性的 C-H 外选择性环化反应，用于咪唑与烯烃的反应。一系列具有β-立体中心的双环或多环咪唑以高达 98%的产率和 >99%的对映选择性得到。双功能 SPO 配体促进的双金属催化被证明对这种具有挑战性的立体控制至关重要。
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