Department of Pathology, Maasstad Hospital, Rotterdam, The Netherlands.
Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
J Cutan Pathol. 2023 Jul;50(7):674-680. doi: 10.1111/cup.14389. Epub 2023 Feb 9.
We present two cases of plaque-type trichoblastoma with atypical foci. A rare variant of trichoblastoma is the plaque variant, which is characterized by poor circumscription and locally infiltrative growth pattern. These lesions mostly require multiple stages of Mohs micrographic surgery. Debate still exists whether this variant should be considered as a benign entity or as "low-grade" malignant counterpart of trichoblastoma. In this report we describe two cases of plaque-type trichoblastoma with atypical foci, which harbored somatic mutations in the Hedgehog pathway, thus should be acknowledged as intermediate malignancies. In addition, extensive molecular workup of both the trichoblastic and atypical component in sequential lesions in the same patient was performed.
我们呈现两例具有非典型灶的斑块型毛发上皮瘤。毛发上皮瘤的一种罕见变异型为斑块型，其特征为边界差和局部浸润性生长方式。这些病变大多需要多次Mohs 显微外科手术。关于该变异型是否应被视为良性实体还是毛发上皮瘤的“低度”恶性对应物，目前仍存在争议。在本报告中，我们描述了两例具有非典型灶的斑块型毛发上皮瘤，这些肿瘤存在 Hedgehog 通路的体细胞突变，因此应被认为是中间型恶性肿瘤。此外，我们对同一患者的连续病变中毛发上皮瘤和非典型成分进行了广泛的分子检测。
