Requena Celia, Requena Luis, Kazakov Dmitry V, Traves Victor, Nagore Eduardo, Llombart Beatriz, Serra Carlos, Guillén Carlos, Sanmartín Onofre
Departments of Dermatology and Pathology, Instituto Valenciano de Oncología, Valencia, Spain.
Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain.
J Cutan Pathol. 2019 Apr;46(4):285-289. doi: 10.1111/cup.13416. Epub 2019 Feb 7.
The plaque variant of trichoblastoma has been described as a solitary tumor with diffuse infiltration of the lower dermis and hypodermis, with poorly defined borders. Herein, we report a new variant of multiple centrofacial trichoblastoma.
To describe clinical and pathological features of a new multiple kind of plaque variant of centrofacial trichoblastoma.
Case series of patients with a multiple-plaque variant of centrofacial trichoblastoma treated in our department between 2005 and 2017. We identified eight patients with the centrofacial plaque variant of trichoblastoma treated in our department from 2005 to 2017.
The final study sample comprised 13 trichoblastomas from four patients. All patients also developed at least one basal cell carcinoma. Mohs surgery was the method of treatment in the majority of the cases of trichoblastoma and in all the cases of basal cell carcinoma. We needed between 2 and 6 stages to obtain free margins in our cases of facial plaque trichoblastomas treated by Mohs surgery.
To the best of our knowledge, a multiple-plaque variant of trichoblastoma has not been described in the literature. We suggest a genetic origin of this variant of trichoblastoma and describe its remarkable infiltrative nature, with poorly defined surgical margins.
毛母细胞瘤的斑块状变异型被描述为一种具有弥漫性浸润真皮下部和皮下组织、边界不清的孤立性肿瘤。在此，我们报告一种新的多中心面部毛母细胞瘤变异型。
描述一种新的多中心面部毛母细胞瘤斑块状变异型的临床和病理特征。
回顾性分析2005年至2017年在我科治疗的多中心面部毛母细胞瘤斑块状变异型患者的病例系列。我们确定了2005年至2017年在我科治疗的8例多中心面部毛母细胞瘤斑块状变异型患者。
最终研究样本包括来自4例患者的13个毛母细胞瘤。所有患者均至少发生1例基底细胞癌。在大多数毛母细胞瘤病例和所有基底细胞癌病例中，莫氏手术是治疗方法。在我们通过莫氏手术治疗的面部斑块状毛母细胞瘤病例中，需要2至6个阶段才能获得切缘阴性。
据我们所知，文献中尚未描述多中心面部毛母细胞瘤的斑块状变异型。我们认为这种毛母细胞瘤变异型具有遗传起源，并描述了其显著的浸润性，手术切缘不清。
