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When it comes to the heart, age, and sex matter (sometimes).
Am J Physiol Heart Circ Physiol. 2023 Feb 1;324(2):H226-H228. doi: 10.1152/ajpheart.00719.2022. Epub 2023 Jan 6.
2
The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model.
Am J Physiol Heart Circ Physiol. 2023 Jan 1;324(1):H141-H154. doi: 10.1152/ajpheart.00497.2022. Epub 2022 Dec 9.
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Validation of a guinea pig Langendorff heart model for assessing potential cardiovascular liability of drug candidates.
J Pharmacol Toxicol Methods. 2009 Sep-Oct;60(2):130-51. doi: 10.1016/j.vascn.2009.07.002. Epub 2009 Jul 18.
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Assessment of the effects of changes in body temperature on cardiac electrophysiology in anaesthetised guinea pigs.
J Pharmacol Toxicol Methods. 2012 Jan;65(1):1-7. doi: 10.1016/j.vascn.2011.11.004. Epub 2011 Dec 8.
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Functional characterisation of the novel histamine H(3) receptor agonist, VUF 5810, on the guinea-pig isolated ileum.
Inflamm Res. 2004 Mar;53 Suppl 1:S77-8. doi: 10.1007/s00011-003-0337-y. Epub 2004 Mar 5.
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Don't overlook overload of calcium.
Heart Rhythm. 2010 Oct;7(10):1436-7. doi: 10.1016/j.hrthm.2010.04.025. Epub 2010 Apr 26.
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Flecainide attenuates rate adaptation of ventricular repolarization in guinea-pig heart.
Scand Cardiovasc J. 2016;50(1):28-35. doi: 10.3109/14017431.2015.1099721. Epub 2015 Oct 20.
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The defibrillation efficacy of high frequency alternating current sinusoidal waveforms in guinea pigs.
Pacing Clin Electrophysiol. 2003 Feb;26(2 Pt 1):599-604. doi: 10.1046/j.1460-9592.2003.00100.x.

引用本文的文献

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Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model.
Sci Rep. 2025 Jul 19;15(1):26270. doi: 10.1038/s41598-025-11390-3.

本文引用的文献

1
The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model.
Am J Physiol Heart Circ Physiol. 2023 Jan 1;324(1):H141-H154. doi: 10.1152/ajpheart.00497.2022. Epub 2022 Dec 9.
2
Reevaluating methods reporting practices to improve reproducibility: an analysis of methodological rigor for the Langendorff whole heart technique.
Am J Physiol Heart Circ Physiol. 2022 Sep 1;323(3):H363-H377. doi: 10.1152/ajpheart.00164.2022. Epub 2022 Jun 24.
3
Demographic and Methodological Heterogeneity in Electrocardiogram Signals From Guinea Pigs.
Front Physiol. 2022 Jun 2;13:925042. doi: 10.3389/fphys.2022.925042. eCollection 2022.
4
Cardiac Pacemaker Activity and Aging.
Annu Rev Physiol. 2020 Feb 10;82:21-43. doi: 10.1146/annurev-physiol-021119-034453. Epub 2019 Nov 22.
6
Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes.
Cardiovasc Res. 2015 Apr 1;106(1):76-86. doi: 10.1093/cvr/cvv046. Epub 2015 Feb 24.
7
Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study.
PLoS Comput Biol. 2010 Jan 29;6(1):e1000658. doi: 10.1371/journal.pcbi.1000658.
8
Characterization of ventricular repolarization in male and female guinea pigs.
J Mol Cell Cardiol. 2007 Feb;42(2):357-66. doi: 10.1016/j.yjmcc.2006.11.004. Epub 2006 Dec 18.
9
Reproduction in female wild guinea-pigs.
J Reprod Fertil. 1970 Dec;23(3):393-409. doi: 10.1530/jrf.0.0230393.

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