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The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model.性别和年龄对离体心脏电生理学的影响：豚鼠模型的见解。
Am J Physiol Heart Circ Physiol. 2023 Jan 1;324(1):H141-H154. doi: 10.1152/ajpheart.00497.2022. Epub 2022 Dec 9.
2
Reevaluating methods reporting practices to improve reproducibility: an analysis of methodological rigor for the Langendorff whole heart technique.重新评估方法报告实践以提高可重复性：Langendorff 全心技术方法严谨性的分析。
Am J Physiol Heart Circ Physiol. 2022 Sep 1;323(3):H363-H377. doi: 10.1152/ajpheart.00164.2022. Epub 2022 Jun 24.
3
Demographic and Methodological Heterogeneity in Electrocardiogram Signals From Guinea Pigs.豚鼠心电图信号中的人口统计学和方法学异质性
Front Physiol. 2022 Jun 2;13:925042. doi: 10.3389/fphys.2022.925042. eCollection 2022.
4
Cardiac Pacemaker Activity and Aging.心脏起搏器活动与衰老。
Annu Rev Physiol. 2020 Feb 10;82:21-43. doi: 10.1146/annurev-physiol-021119-034453. Epub 2019 Nov 22.
5
Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs.性别相关的药物诱导 QT 间期延长和尖端扭转型室性心动过速的差异：具有人诱导多能干细胞心肌细胞的新型模型系统。
Toxicol Sci. 2019 Feb 1;167(2):360-374. doi: 10.1093/toxsci/kfy239.
6
Ageing is associated with deterioration of calcium homeostasis in isolated human right atrial myocytes.衰老与离体人右心房肌细胞钙稳态的恶化有关。
Cardiovasc Res. 2015 Apr 1;106(1):76-86. doi: 10.1093/cvr/cvv046. Epub 2015 Feb 24.
7
Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study.性类固醇激素对心律失常易感性的急性影响：一项模拟研究。
PLoS Comput Biol. 2010 Jan 29;6(1):e1000658. doi: 10.1371/journal.pcbi.1000658.
8
Characterization of ventricular repolarization in male and female guinea pigs.
J Mol Cell Cardiol. 2007 Feb;42(2):357-66. doi: 10.1016/j.yjmcc.2006.11.004. Epub 2006 Dec 18.
9
Reproduction in female wild guinea-pigs.
J Reprod Fertil. 1970 Dec;23(3):393-409. doi: 10.1530/jrf.0.0230393.
10
Expression of sarcoplasmic reticulum Ca(2+)-ATPase and calsequestrin genes in rat heart during ontogenic development and aging.
Circ Res. 1991 Nov;69(5):1380-8. doi: 10.1161/01.res.69.5.1380.

When it comes to the heart, age, and sex matter (sometimes).

作者信息

Weinberg Seth H, King D Ryan

机构信息

Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio.

Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.

出版信息

Am J Physiol Heart Circ Physiol. 2023 Feb 1;324(2):H226-H228. doi: 10.1152/ajpheart.00719.2022. Epub 2023 Jan 6.

DOI:10.1152/ajpheart.00719.2022
PMID:36607802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9886353/
Abstract
摘要