Bi Ye, Lin Hai-Yan, Li Ming-Long, Zhou Jie, Sun Xiang-Lan
From the Department of Geriatric Endocrinology.
Physical Examination Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Pancreas. 2022 Sep 1;51(8):1000-1006. doi: 10.1097/MPA.0000000000002138.
To date, the complete natural history of pancreatic steatosis is unknown. This study aimed to investigate the association of fatty pancreas (FP) in the incidence of metabolic syndrome and its components among Chinese patients with a 5-year follow-up.
Three independent cross-sectional surveys were carried out in 2013, 2015, and 2018. Fatty pancreas was diagnosed via transabdominal sonography. Logistic regression analysis was used to estimate the correlation between FP and metabolic syndrome. New cases of metabolic syndrome and its components were estimated by Cox proportional hazards models.
At baseline, 12,551 individuals classified into FP (n = 1010) and non-FP (n = 11,541) groups were finally enrolled. In cross-sectional analyses, odds ratio of FP was 2.378 (95% confidence interval [CI], 2.085-2.713; P < 0.001). In longitudinal analyses, FP was associated with the occurrence of metabolic syndrome (hazard ratio [HR], 3.179; 95% CI, 2.197-4.6; P < 0.001), type 2 diabetes mellitus (HR, 13.99; 95% CI, 7.865-24.883; P < 0.001), nonalcoholic fatty liver disease (HR, 31.843; 95% CI, 7.73-131.171; P < 0.001), and hypertension (HR, 12.801; 95% CI, 7.323-22.38; P < 0.001).
Pancreatic steatosis is strongly associated with the occurrence of metabolic syndrome and its components such as hypertension and diabetes.
迄今为止，胰腺脂肪变性的完整自然病史尚不清楚。本研究旨在通过对中国患者进行5年随访，调查胰腺脂肪变性（FP）与代谢综合征及其各组分发病率之间的关联。
于2013年、2015年和2018年进行了三项独立的横断面调查。通过经腹超声诊断胰腺脂肪变性。采用逻辑回归分析评估FP与代谢综合征之间的相关性。通过Cox比例风险模型估计代谢综合征及其各组分的新发病例。
在基线时，最终纳入了分为FP组（n = 1010）和非FP组（n = 11541）的12551名个体。在横断面分析中，FP的优势比为2.378（95%置信区间[CI]，2.085 - 2.713；P < 0.001）。在纵向分析中，FP与代谢综合征的发生相关（风险比[HR]，3.179；95%CI，2.197 - 4.6；P < 0.001），2型糖尿病（HR，13.99；95%CI，7.865 - 24.883；P < 0.001），非酒精性脂肪性肝病（HR，31.843；95%CI，7.73 - 131.171；P < 0.001），以及高血压（HR，12.801；95%CI，7.323 - 22.38；P < 0.001）。
胰腺脂肪变性与代谢综合征及其组分如高血压和糖尿病的发生密切相关。
