Department of Gastroenterology, Mersin University Faculty of Medicine, Mersin, Turkey.
Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey.
Turk J Gastroenterol. 2024 Mar;35(3):239-254. doi: 10.5152/tjg.2024.23583.
BACKGROUND/AIMS: Pancreatic steatosis (PS) is a pathology associated with metabolic syndrome (MS), endocrin and exocrine disfunctions of the pancreas, and fatty liver. The data on the frequency of PS are very limited. We aimed to evaluate the frequency of PS detected by transabdominal ultrasonography (TAU) in gastroenterology clinics located in different geographical regions of Turkey and the factors associated with it.
Volunteers were evaluated by TAU for PS and hepatosteatosis (HS), and its degree. Pancreatic stiffness was evaluated by ultrasonographic shear wave elastography (SWE). All demographic, physical, and biochemical parametres were measured.
A total of 1700 volunteers from 14 centers throughout Turkey were included in the study. Mean age was 48.03 ± 20.86 years (56.9% female). Prevalance of PS was detected in 68.9%. In the PS group, age, body mass index (BMI), waist circumference, systolic blood pressure, fasting blood glucose (FBG), lipid levels, insulin resistance, diabetes mellitus, hypertension, MS frequency, and pancreatic SWE score were increasing, and fecal elastase level was decreasing in correlation with the degree of PS. The frequency of HS was 55.5%. Hepatosteatosis [odds ratio (OR): 9.472], increased age (OR: 1.02), and BMI (OR: 1.089) were independent risk factors for the occurrence of PS. Lean-PS rate was 11.8%. The lean-PS group was predominantly female and younger than non-lean PS. Also it has lower blood pressure, FBG, liver enzymes, lipid levels, and HS rates.
The frequency of PS was found 68.9% in Turkey. Its relationship was determined with age, BMI, HS, MS (and its components), pancreatic stiffness, and fecal elastase level.
背景/目的：胰腺脂肪变性（PS）是一种与代谢综合征（MS）、胰腺内分泌和外分泌功能障碍以及脂肪肝相关的病理学。关于 PS 发生率的数据非常有限。我们旨在评估在土耳其不同地理位置的胃肠病学诊所通过腹部超声（TAU）检测到的 PS 频率及其相关因素。
志愿者通过 TAU 评估 PS 和肝脂肪变性（HS）及其程度。通过超声剪切波弹性成像（SWE）评估胰腺硬度。测量所有人口统计学、身体和生化参数。
共有来自土耳其 14 个中心的 1700 名志愿者参与了这项研究。平均年龄为 48.03 ± 20.86 岁（56.9%为女性）。检测到 PS 的患病率为 68.9%。在 PS 组中，年龄、体重指数（BMI）、腰围、收缩压、空腹血糖（FBG）、血脂水平、胰岛素抵抗、糖尿病、高血压、MS 频率和胰腺 SWE 评分随着 PS 程度的增加而增加，而粪便弹性蛋白酶水平则随之降低。HS 的发生率为 55.5%。HS[比值比（OR）：9.472]、年龄增加（OR：1.02）和 BMI（OR：1.089）是 PS 发生的独立危险因素。瘦 PS 发生率为 11.8%。瘦 PS 组以女性为主，且年龄小于非瘦 PS 组。此外，其血压、FBG、肝酶、血脂和 HS 发生率也较低。
在土耳其，PS 的发生率为 68.9%。其与年龄、BMI、HS、MS（及其组成部分）、胰腺硬度和粪便弹性蛋白酶水平有关。
