噬菌体疗法：从生物学机制到未来方向。
Phage therapy: From biological mechanisms to future directions.
机构信息
Center for Innovative Phage Applications and Therapeutics, Division of Infectious Disease and Global Public Health, University of California, San Diego, La Jolla, CA 92093-0507, USA.
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
出版信息
Cell. 2023 Jan 5;186(1):17-31. doi: 10.1016/j.cell.2022.11.017.
Abstract
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years ago. In order to use phages therapeutically, they should (1) preferably be lytic, (2) kill the bacterial host efficiently, and (3) be fully characterized to exclude side effects. Developing therapeutic phages takes a coordinated effort of multiple stakeholders. Herein, we review the state of the art in phage therapy, covering biological mechanisms, clinical applications, remaining challenges, and future directions involving naturally occurring and genetically modified or synthetic phages.
摘要
随着抗菌药物耐药率的不断上升，100 多年前被发现的细菌“天然捕食者”噬菌体（phage）的研究重新受到关注。为了将噬菌体用于治疗，它们应该（1）最好是裂解性的，（2）有效地杀死细菌宿主，并且（3）经过充分的特性描述以排除副作用。开发治疗性噬菌体需要多个利益相关者的协调努力。本文综述了噬菌体治疗的最新进展，涵盖了生物学机制、临床应用、尚存挑战以及涉及天然存在的、经过基因修饰的或合成的噬菌体的未来方向。
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