Imperial College London, United Kingdom.
University of Rochester, Monroe County, New York.
J Am Acad Child Adolesc Psychiatry. 2023 Jun;62(6):618-620. doi: 10.1016/j.jaac.2022.11.010. Epub 2023 Jan 3.
Fetal programming is a core concept within the broader developmental origins of health and disease framework, which acknowledges the contribution of the prenatal and early postnatal environment to health across the life span. Fetal programming suggests that the fetus adapts to environmental exposures and that altered biological systems can have lasting effects on child and adult health. The theory derived from the widely replicated finding that infants who are smaller at birth are more likely to die of cardiovascular disease in later life. Although initially concerned with cardiometabolic phenotypes, the model has been extended to other systems, including neural development and psychiatric phenotypes.
胎儿编程是健康与疾病的发育起源这一更为广泛的概念框架中的一个核心概念，它承认产前和出生后早期环境对整个生命周期健康的贡献。胎儿编程表明，胎儿适应环境暴露，改变的生物系统可能对儿童和成人健康产生持久影响。该理论源于广泛复制的发现，即出生时较小的婴儿在以后的生活中死于心血管疾病的可能性更大。尽管最初关注的是心脏代谢表型，但该模型已经扩展到其他系统，包括神经发育和精神表型。
