Xia Yuanyou, Xu Xiaoyang, Wang Siyao
Health Management Center, Chongqing General Hospital, Chongqing University, Chongqing, 401147, China.
Health Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, 400010, China.
BMC Womens Health. 2024 Dec 30;24(1):670. doi: 10.1186/s12905-024-03538-6.
Age-related cataract (ARC) is among the most common blinding eye disorders among the elderly. Prenatal nutrition may cause irreversible damage to the development of the ocular crystalline lens. Nevertheless, the potential association between prenatal malnutrition and age-related cataract has not been thoroughly examined. We investigated the prevalence of cataract at the age of 60 after prenatal exposure to Chinese famine (1959-1961) and particularly evaluated whether there was a disparity in this effect between men and women.
We utilized the health examination medical record system of a large-scale comprehensive hospital to screen individuals born in Chongqing, China and undergoing eye health examinations. Participants were categorized based on their year of birth into the famine-exposed group (1960) and the non-exposed group (1963), with their medical records at age 60 extracted from the database. Univariate and multivariate logistic regression analyses were conducted to investigate the association between famine exposure and the risk of developing ARC by age 60.
The prevalence of ARC was significantly higher in the famine-exposed group (60.26%) compared to the non-exposed group (47.90%) (P < 0.001). After adjusting for diabetes history, body mass index (BMI), fasting blood glucose (FBG) level, and high-density lipoprotein (HDL) level using multivariate logistic regression analysis, the risk of ARC remained significantly higher in the famine-exposed group (OR:1.63; 95%CI:1.31-2.03). Subgroup analysis by sex indicated that women exposed to famine (OR: 1.77; 95% CI: 1.25-2.52) exhibited a higher risk of ARC compared to men (OR: 1.53; 95% CI: 1.16-2.03).
Prenatal exposure to famine might increase the risk of ARC among Chinese adults at age 60, and women exhibit a higher susceptibility than men.
年龄相关性白内障（ARC）是老年人中最常见的致盲性眼病之一。产前营养可能会对眼晶状体的发育造成不可逆的损害。然而，产前营养不良与年龄相关性白内障之间的潜在关联尚未得到充分研究。我们调查了产前暴露于中国饥荒时期（1959 - 1961年）的人群60岁时白内障的患病率，并特别评估了这种影响在男性和女性之间是否存在差异。
我们利用一家大型综合医院的健康检查医疗记录系统，筛选出生于中国重庆且接受眼部健康检查的个体。参与者根据出生年份分为饥荒暴露组（1960年）和非暴露组（1963年），从数据库中提取他们60岁时的医疗记录。进行单因素和多因素逻辑回归分析，以研究饥荒暴露与60岁时发生年龄相关性白内障风险之间的关联。
饥荒暴露组的年龄相关性白内障患病率（60.26%）显著高于非暴露组（47.90%）（P < 0.001）。使用多因素逻辑回归分析调整糖尿病史、体重指数（BMI）、空腹血糖（FBG）水平和高密度脂蛋白（HDL）水平后，饥荒暴露组发生年龄相关性白内障的风险仍然显著更高（比值比：1.63；95%置信区间：1.31 - 2.03）。按性别进行的亚组分析表明，与男性（比值比：1.53；95%置信区间：1.16 - 2.03）相比，暴露于饥荒的女性（比值比：1.77；95%置信区间：1.25 - 2.52）发生年龄相关性白内障的风险更高。
产前暴露于饥荒可能会增加中国60岁成年人患年龄相关性白内障的风险，且女性比男性更易患病。
