Miederer S E, Schmidt C
Medizinische Klinik des Ev. Johannes Krankenhauses Bielefeld.
Z Gastroenterol. 1987 Aug;25 Suppl 3:130-5.
In the last years the importance of the evaluation of antacid compounds according to their neutralizing capacity decreased. Clinical investigations have shown that antacid mixtures of aluminum-magnesium hydroxide healed gastric an duodenal ulcers (neutralizing capacity 100-150 mmol/day) as well as H2 receptor antagonists and better than a placebo. By this the necessary daily dosage could be reduced essentially. This paper presents studies showing that lattice like structured antacids (e.g. Magaldrate) healed gastric and duodenal ulcers (neutralizing capacity 100-350 mmol/day) as well as Ranitidine (150 mg b.d.). Maintenance therapy should be evaluated critically because sufficient data are not available and mineral metabolism is changed significantly by extremely small dosages of aluminium-magnesium hydroxide antacids even in patients with normal kidney function.
在过去几年中，根据抗酸化合物的中和能力进行评估的重要性有所降低。临床研究表明，氢氧化铝镁抗酸混合物治愈胃溃疡和十二指肠溃疡（中和能力为100 - 150 mmol/天）的效果与H2受体拮抗剂相当，且优于安慰剂。由此，每日所需剂量可大幅降低。本文的研究表明，晶格状结构的抗酸剂（如氢氧化铝镁）治愈胃溃疡和十二指肠溃疡（中和能力为100 - 350 mmol/天）的效果与雷尼替丁（每日两次，每次150 mg）相当。维持治疗应进行严格评估，因为目前尚无足够数据，而且即使是肾功能正常的患者，极小剂量的氢氧化铝镁抗酸剂也会显著改变矿物质代谢。
