Univ Lyon, University Cla-ude Bernard Lyon-1, CNRS, ISA-UMR 5280, Lyon, France.
Expert Opin Drug Deliv. 2023 Feb;20(2):189-204. doi: 10.1080/17425247.2023.2166484. Epub 2023 Jan 16.
Cancer has one of the highest mortality rates globally. The traditional therapies used to treat cancer have harmful adverse effects. Considering these facts, researchers have explored new therapeutic possibilities with enhanced benefits. Nanoparticle development for cancer detection, in addition to therapy, has shown substantial progress over the past few years.
Herein, the latest research regarding cancer treatment employing magnetic nanoparticles (MNPs) in chemo-, immuno-, gene-, and radiotherapy along with hyperthermia is summarized, in addition to their physio-chemical features, advantages, and limitations for clinical translation have also been discussed.
MNPs are being extensively investigated and developed into effective modules for cancer therapy. They are highly functional tools aimed at cancer therapy owing to their excellent superparamagnetic, chemical, biocompatible, physical, and biodegradable properties.
癌症是全球死亡率最高的疾病之一。传统的癌症治疗方法具有有害的副作用。考虑到这些事实,研究人员已经探索了具有增强效益的新的治疗可能性。在过去几年中,用于癌症检测的纳米颗粒的开发,除了治疗之外,也取得了很大的进展。
本文总结了目前利用磁性纳米颗粒(MNPs)在化疗、免疫、基因和放射治疗以及热疗方面治疗癌症的最新研究进展,同时还讨论了其理化特性、在临床转化方面的优缺点。
MNPs 正在被广泛研究,并被开发成癌症治疗的有效模块。由于其具有优异的超顺磁性、化学、生物相容性、物理和可生物降解性等特性,它们是非常有效的癌症治疗工具。