Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Mater Sci Eng C Mater Biol Appl. 2019 May;98:930-938. doi: 10.1016/j.msec.2019.01.038. Epub 2019 Jan 9.
Hyperthermia-increasing temperature of cancerous tissue for a short period of time-is considered as an effective treatment for various cancer types such as malignant bone tumors. Superparamagnetic and ferromagnetic particles have been studied for their hyperthermic properties in treating various types of cancers. The activation of magnetic nanoparticles by an alternating magnetic field is currently being explored as a technique for targeted therapeutic heating of different tumors and is being studied as an adjuvant to conventional chemotherapy and radiation therapy. In the case of bone cancers, to increase the efficiency of treatment in the hyperthermia therapy, employed materials should support bone regeneration as well. Magnetite is one of the most attractive magnetic nanoceramics used in hyperthermia application. However, biocompatibility and bioactivity of this material have raised questions. There is a high demand for extremely efficient hyperthermia materials which are equally biocompatible to non-tumor cells and tissues. We report the development of a biocompatible and bioactive material with desirable magnetic properties that show excellent hyperthermia properties and can be used for destruction of the cancerous tissue in addition to supporting tissue regeneration for treatment of bone tumors. In the current study, iron (Fe)-containing HT nanostructured material was prepared, and its biocompatibility, bioactivity, and hyperthermia abilities were studied. The developed materials showed effective hyperthermic properties with increased biocompatibility as compared to magnetite.
热疗——短时间内提高癌组织的温度——被认为是治疗各种癌症类型的有效方法，例如恶性骨肿瘤。超顺磁和铁磁颗粒因其在治疗各种类型癌症方面的热疗特性而被研究。目前，正在研究通过交变磁场激活磁性纳米粒子作为治疗不同肿瘤的靶向治疗加热技术，并作为常规化疗和放射治疗的辅助手段进行研究。在骨癌的情况下，为了提高热疗的治疗效率，所使用的材料也应该支持骨再生。磁铁矿是用于热疗应用的最具吸引力的磁性纳米陶瓷之一。然而，这种材料的生物相容性和生物活性引发了疑问。人们对同样对非肿瘤细胞和组织具有生物相容性的极高效率的热疗材料有很高的需求。我们报告了一种具有理想磁性的生物相容性和生物活性材料的开发，该材料具有出色的热疗性能，除了支持组织再生以治疗骨肿瘤外，还可以用于破坏癌组织。在目前的研究中，制备了含铁（Fe）的 HT 纳米结构材料，并研究了其生物相容性、生物活性和热疗能力。与磁铁矿相比，所开发的材料表现出有效的热疗特性和提高的生物相容性。
