Urogenital System Clinical and Experimental Research Unit (UPCEURG), Federal University of Pará (UFPA), Belém, Brazil.
Genetics and Molecular Biology Research Unit (UPGEM), São José do Rio Preto Medical School (FAMERP), São José do Rio Preto, Brazil.
Childs Nerv Syst. 2023 Jul;39(7):1773-1782. doi: 10.1007/s00381-022-05779-y. Epub 2023 Jan 7.
This study aimed to verify possible associations between sociodemographic and clinical factors in live births with spinal dysraphism.
An analytical (descriptive and inferential) and ecological study was carried out based on secondary data of 11,308 live births with spinal dysraphism registered in the Live Birth Information System (SINASC) in Brazil from 1999 to 2019. Demographic factors analyzed were age, education, mothers' marital status and geographic region. The clinical factors analyzed were duration, gestation period, birthweight, and number of prenatal visits performed by women who underwent medical follow-up.
There was an increase in the number of cases of spinal dysraphism in recent years in Brazil with an annual percentage variation of 3.52%. However, the period from 2005 to 2009 showed a reduction in live births with spinal dysraphism. The regions with the highest incidence were the South and Southeast. The risk increased in mothers born after 1980, older than 30 years and with a high level of education. The risk was increased in live births of whites and blacks, born from double pregnancy and with body weight less than 3000 g. The absence of prenatal care was associated with a higher incidence.
Sociodemographic and clinical factors have specific characteristics that can predict spinal dysraphism in newborns in Brazil.
本研究旨在验证活产儿伴发脊髓脊膜膨出的社会人口学和临床因素之间的可能关联。
本研究基于巴西 1999 年至 2019 年出生信息系统(SINASC)中登记的 11308 例伴发脊髓脊膜膨出的活产儿的二级数据,进行了分析性(描述性和推断性)和生态学研究。分析的人口学因素包括年龄、教育程度、母亲的婚姻状况和地理区域。分析的临床因素包括持续时间、孕期、出生体重以及接受医学随访的女性进行的产前检查次数。
近年来,巴西伴发脊髓脊膜膨出的病例数量有所增加,年百分比变化为 3.52%。然而,2005 年至 2009 年期间,伴发脊髓脊膜膨出的活产儿数量有所减少。发病率最高的地区是南部和东南部。出生于 1980 年后、年龄大于 30 岁且受教育程度较高的母亲,患病风险增加。白人及黑人、双胎妊娠和出生体重低于 3000 克的活产儿,患病风险增加。产前护理缺失与发病率升高相关。
社会人口学和临床因素具有特定特征,可预测巴西新生儿伴发脊髓脊膜膨出的风险。