参与艾滋病毒护理的跨性别女性的临床和行为结果：与艾滋病研究网络综合临床系统（CNICS）队列中的顺性别男性和女性的比较。
Clinical and Behavioral Outcomes for Transgender Women Engaged in HIV Care: Comparisons to Cisgender Men and Women in the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) Cohort.
机构信息
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, USA.
出版信息
AIDS Behav. 2023 Jul;27(7):2113-2130. doi: 10.1007/s10461-022-03947-4. Epub 2023 Jan 6.
Describe health of transgender women (TW) with HIV vs. cisgender men and women (CM, CW) in a U.S. HIV care cohort. Data were from Centers for AIDS Research Network of Integrated Clinical Systems (CNICS), 2005-2022. TW were identified using clinical data/identity measures. PWH (n = 1285) were included in analyses (275 TW, 547 CM, 463 CW). Cross-sectional multivariable analyses compared HIV outcomes/co-morbidities between TW/CM and TW/CW, and adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) were estimated. TW had poorer adherence (> 90% adherent; aOR 0.57; 95%CI 0.38, 0.87) and were more likely to miss ≥ 3 visits in the past year than CM (aOR 1.50, 95%CI 1.06, 2.10); indicated more anxiety compared to both CM and CW (p ≤ 0.001, p = 0.02); hepatitis C infection (p = 0.03) and past-year/lifetime substance treatment (p = 0.004/p = 0.001) compared to CM; and substance use relative to CW. TW with HIV differed in HIV clinical outcomes and co-morbidities from CM and CW.
描述美国艾滋病毒护理队列中跨性别女性 (TW) 与顺性别男性和女性 (CM、CW) 的健康状况。数据来自艾滋病研究中心网络综合临床系统 (CNICS)，2005-2022 年。TW 通过临床数据/身份措施确定。包括分析在内的 PWH（n=1285）（275 TW、547 CM、463 CW）。横断面多变量分析比较了 TW/CM 和 TW/CW 之间的艾滋病毒结局/合并症，并估计了调整后的优势比 (aOR) 和 95%置信区间 (95%CI)。TW 的依从性较差（>90%依从性；aOR 0.57；95%CI 0.38,0.87），并且在过去一年中错过≥3 次就诊的可能性高于 CM（aOR 1.50，95%CI 1.06,2.10）；与 CM 和 CW 相比，TW 表示更多的焦虑（p≤0.001，p=0.02）；丙型肝炎感染（p=0.03）和过去一年/终生药物治疗（p=0.004/p=0.001）比 CM 更常见；以及相对于 CW 的药物使用。HIV 阳性的 TW 在 HIV 临床结局和合并症方面与 CM 和 CW 不同。
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