Nielsen Marcus M. K., Aryal Eva, Safari Elnaz, Mojsoska Biljana, Jenssen Håvard, Prabhala Bala Krishna
Institute of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark.
Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia 5756151818, Iran.
Proteomes. 2021 May 16;9(2):23. doi: 10.3390/proteomes9020023.
With a relatively large surface area (2 m) and 15% of total body mass, the skin forms the largest organ of the human body. The main functions of the skin include regulation of body temperature by insulation or sweating, regulation of the nervous system, regulation of water content, and protection against external injury. To perform these critical functions, the skin encodes genes for transporters responsible for the cellular trafficking of essential nutrients and metabolites to maintain cellular hemostasis. However, the knowledge on the expression, regulation, and function of these transporters is very limited and needs more work to elucidate how these transporters play a role both in disease progression and in healing. Furthermore, SLC and ABC transporters are understudied, and even less studied in skin. There are sparse reports on relation between transporters in skin and sweat metabolites. This mini review focuses on the current state of SLC and ABC transporters in the skin and their relation to sweat metabolites and skin diseases.
皮肤表面积相对较大（2平方米），占总体重的15%，是人体最大的器官。皮肤的主要功能包括通过隔热或出汗调节体温、调节神经系统、调节水分含量以及防止外部损伤。为了执行这些关键功能，皮肤编码负责将必需营养物质和代谢产物进行细胞运输以维持细胞内稳态的转运蛋白基因。然而，关于这些转运蛋白的表达、调控和功能的知识非常有限，需要更多研究来阐明它们在疾病进展和愈合过程中是如何发挥作用的。此外，溶质载体（SLC）和ATP结合盒（ABC）转运蛋白的研究较少，在皮肤中的研究更少。关于皮肤转运蛋白与汗液代谢产物之间关系的报道也很少。本综述聚焦于皮肤中SLC和ABC转运蛋白的现状及其与汗液代谢产物和皮肤疾病的关系。
